镁基表面不同改性涂层的生物学行为研究

镁基表面不同改性涂层的生物学行为研究摘要：

随着人类对生物材料需求的不断增加，镁合金因其良好的生物相容性和生物可降解性，成为了一种备受关注的生物医用材料。但是，随着异常反应的不断发生，镁合金的临床应用受到了一定程度的限制。为了克服这些问题，近年来涂层技术成为一种很重要的改善镁合金生物相容性的方法。然而，目前针对镁基材料涂层还存在很多问题需要研究，比如涂层的材料、结构、组成等等。

本文综述了目前常用的镁基表面改性涂层，并介绍了这些涂层的生物学行为研究进展。我们认为，各种涂层材料的组合和结构对于生物学行为的影响是不同的。因此，我们对比研究了不同改性涂层的生物学行为，包括材料的生物相容性、生物腐蚀性、细胞黏附和增殖、异物反应等等。此外，我们探究了涂层表面化学特性对细胞黏附和增殖的影响，从而更全面地了解改性涂层的作用机制。

研究结果表明，镁基表面改性涂层可以显著改善镁合金的生物学性能，并且不同的涂层材料和结构对生物学行为产生了不同的影响。此外，表面化学特性也是影响细胞黏附和增殖的重要因素。综上，针对镁基材料涂层的生物学行为研究具有重要的价值，对于提高镁合金的应用前景具有重要的意义。

关键词：镁基涂层；生物学行为；表面化学特性；生物相容性；生物可降解性；异物反应；细胞黏附；维持性能。

Abstract:

Withtheincreasingdemandforbiomaterials,magnesiumalloyhasbecomeawidelystudiedandpromisingbiomedicalmaterialduetoitsexcellentbiocompatibilityandbiodegradability.However,clinicalapplicationofmagnesiumalloyislimitedbytheoccurrenceofadversereactions.Inrecentyears,coatingtechnologyhasbecomeanimportantmethodtoimprovethebiocompatibilityofmagnesiumalloy.However,therearestillmanyproblemstobesolvedincoatingmagnesium-basedmaterials,suchascoatingmaterials,structure,andcomposition,etc.

Inthispaper,wereviewthecommonlyusedmagnesium-basedsurfacemodificationcoatingsandtheresearchprogressontheirbiologicalbehavior.Webelievethatthecombinationandstructureofdifferentcoatingmaterialshavedifferenteffectsonbiologicalbehavior.Therefore,wecomparethebiologicalbehaviorofdifferentmodifiedcoatings,includingbiocompatibility,biodegradability,celladhesionandproliferation,andforeignbodyreaction.Inaddition,weexploredtheeffectsofsurfacechemicalpropertiesoncelladhesionandproliferationtogainamorecomprehensiveunderstandingofthemechanismofactionofmodifiedcoatings.

Theresultsshowthatmagnesium-basedsurfacemodificationcoatingscansignificantlyimprovethebiologicalpropertiesofmagnesiumalloy,anddifferentcoatingmaterialsandstructureshavedifferenteffectsonbiologicalbehavior.Inaddition,surfacechemicalpropertiesarealsoanimportantfactoraffectingcelladhesionandproliferation.Therefore,furtherresearchonthebiologicalbehaviorofmagnesium-basedcoatingsisofgreatvalueandsignificanceforimprovingtheapplicationprospectofmagnesiumalloy.

Keywords:magnesium-basedcoatings;biologicalbehavior;surfacechemicalproperties;biocompatibility;biodegradability;foreignbodyreaction;celladhesion;maintenanceofpropertiesMagnesium-basedcoatingshavereceivedsignificantattentionduetotheirpotentialapplicationinvariousbiodegradablemedicaldevices.However,thebiologicalbehaviorofthesecoatingsiscriticalindeterminingtheirefficacyandpracticalityinsuchapplications.Biocompatibilityandbiodegradabilityaretwoessentialfactorsthatdeterminethebiologicalbehaviorofmagnesium-basedcoatings.

Oneofthecriticalfactorsinthebiocompatibilityofmagnesium-basedcoatingsistheirabilitytoavoidanundesiredforeignbodyreactionbythehosttissue.Thisreactionisoftencharacterizedbyinflammationandencapsulationoftheimplant,leadingtopoorintegrationandfunctioninthehost.Therefore,studiesneedtofocusondevelopingcoatingsthatcanavoidorminimizeforeignbodyreactions.

Celladhesionandproliferationareotherimportantaspectsofthebiologicalbehaviorofmagnesium-basedcoatings.Thesurfacechemicalpropertiesofthecoatingsplayacriticalroleindeterminingtheadhesionandproliferationofcells.Therefore,researchersmusttakeintoaccountthesurfacepropertieswhiledevelopingthecoatings.

Thebiodegradabilityofmagnesium-basedcoatingsisalsoanessentialaspectthataffectstheirbiologicalbehavior.Therateofdegradationofcoatingsshouldmatchtherateoftissuehealingtoavoidanyadverseeffectsonthehealingprocess.Moreover,thebyproductsofthedegradationprocessmustbebiocompatiblewiththehosttissue.

Inconclusion,furtherresearchonthebiologicalbehaviorofmagnesium-basedcoatingsiscrucialinenhancingtheirapplicationprospectinvariousbiodegradablemedicaldevices.Biocompatibility,biodegradability,foreignbodyreactions,celladhesion,andmaintenanceofpropertiesarekeyfactorsthatmustbetakenintoaccounttooptimizetheireffectivenessintheseapplicationsMagnesium-basedcoatingshavegainedattentionaspotentialbiodegradablematerialsinmedicalapplicationsduetotheiruniqueproperties.However,therearestillsomechallengesthatneedtobeaddressedbeforetheirwidespreaduseinclinicalsettingscanbeachieved.

Oneofthemajorchallengesisimprovingtheircorrosionresistance.Therapiddegradationofmagnesium-basedcoatingscanleadtoprematurefailureofmedicalimplants,causingadverseeffectsonthehosttissue.Topreventthis,severalapproacheshavebeenproposed,includingtheadditionofalloyingelementsandsurfacemodificationusingplasmaspraying,electrochemicaldeposition,orsol-gelprocessing.

Anotherchallengeistheforeignbodyreactionthatcanoccurwhenmagnesium-basedcoatingsareimplantedinvivo.Thisreactioninvolvestheactivationofthehostimmunesystem,whichcanresultininflammationandtissuedamage.Toaddressthisissue,researchershavebeenexploringdifferentsurfacemodifications,suchastheuseofcoatingsthatmimictheextracellularmatrixtopromotecelladhesionandreduceinflammation.

Inaddition,themechanicalpropertiesofmagnesium-basedcoatingsneedtobeoptimizedtoensuretheirlong-termperformance.Forexample,thecoatingsshouldmaintaintheirstrengthandelasticityovertimetowithstandthestressesandstrainsofthehosttissueenvironment.

Finally,thedegradationbyproductsofmagnesium-basedcoatingsmustbebiocompatibletoensurethattheydonotcauseanyadverseeffects.Researchershavebeeninvestigatingdifferentstrategiesfortuningthedegradationrateofthesecoatings,suchastailoringthecoatingthicknessorthecompositionofthealloy.

Overall,magnesium-basedcoatingshaveimmensepotentialinthefieldofbiodegradablemedicaldevicesduetotheirbiocompatibilityandbiodegradability.ContinuedresearchanddevelopmentofthesecoatingsisessentialtoovercometheexistingchallengesandtoexpandtheirapplicationprospectsinawiderangeofbiomedicalapplicationsOneareawheremagnesium-basedcoatingsshowgreatpromiseisinorthopedicimplants.Orthopedicimplantsareusedtoreplaceorrepairdamagedordiseasedboneandjointtissue.Traditionally,orthopedicimplantshavebeenmadeofmaterialssuchastitanium,stainlesssteel,andcobalt-chromiumalloys.Whilethesematerialsarestronganddurable,theyarenotbiodegradableandcancauselong-termproblemsinsomepatients.Forexample,metalimplantscaninterferewithmagneticresonanceimaging(MRI)andcancauseallergicreactionsortoxicityovertime.

Magnesium-basedcoatingsofferanumberofadvantagesovertraditionalorthopedicimplantmaterials.First,theyarebiodegradable,whichmeansthattheynaturallydegradeovertime,eliminatingtheneedforadditionalsurgeriestoremovetheimplant.Thisisparticularlyimportantforpediatricpatientswhomayrequiremultiplesurgeriesastheygrow.Additionally,magnesium-basedcoatingsarelightweightandbiocompatible,whichmeansthattheyarelesslikelytocauseinflammationorrejectionbythepatient'simmunesystem.

Anotheradvantageofmagnesium-basedcoatingsisthattheyarehighlycustomizable.Magnesiumalloyscanbetailoredtohavespecificmechanicalandcorrosionproperties,whichmeansthattheycanbedesignedtomatchthestrengthanddurabilityrequirementsofdifferentapplications.Additionally,thethicknessandcompositionofthecoatingscanbeadjustedtocontroltherateofdegradation,allowingthemtobecustomizedfordifferentpatientneeds.

Despitetheseadvantages,therearestillseveralchallengesthatmustbeovercomebeforemagnesium-basedcoatingscanbewidelyusedinorthopedicimplants.Onechallengeisthatmagnesiumalloystendtocorrodequicklyinthepresenceofbodyfluids,whichcancompromisetheirstructuralintegrityandreleasepotentiallytoxicbyproducts.Researchersareworkingonwaystoimprovethecorrosionresistanceofmagnesiumalloysbyadjustingtheircompositionordevelopingnewcoatingtechnologies.

Anotherchallengeisthatthedegradationproductsofmagnesiumalloyscancauseinflammationorotheradverseeffectsinsomepatients.Thisisthoughttoberelatedtotheproductsofmagnesiumionhydrolysis,whicharegeneratedasthecoatingdegrades.Researchers