清痰化瘀安神汤治疗痰瘀互结型糖尿病伴失眠的临床研究

清痰化瘀安神汤治疗痰瘀互结型糖尿病伴失眠的临床研究清痰化瘀安神汤治疗痰瘀互结型糖尿病伴失眠的临床研究

摘要：目的：探讨清痰化瘀安神汤治疗痰瘀互结型糖尿病伴失眠的临床效果和治疗机制。方法：选取2018年1月至2020年1月在我院住院并确诊为糖尿病且伴有失眠症状的70例患者，根据痰瘀互结程度分为3组，随机分组给予清痰化瘀安神汤组、二甲双胍组和安神药物组治疗，治疗6周后进行疗效评估，并观察患者心理行为等不良反应。结果：治疗后，三组患者的空腹血糖、餐后2小时血糖和睡眠质量均显著改善，清痰化瘀安神汤组疗效优于其他两组(P＜0.01)。治疗后，清痰化瘀安神汤组血浆生化指标及血流变学指标均有所改善，且均优于其他两组(P＜0.05)。结论：清痰化瘀安神汤治疗痰瘀互结型糖尿病伴失眠的疗效优于二甲双胍和安神药物，能够改善患者的血糖水平、睡眠质量及心理行为状态。其可能机制为清除痰浊、活血化瘀、安神止痛、平衡开窍等多种作用的综合效应。

关键词：清痰化瘀安神汤；痰瘀互结型糖尿病；失眠；疗效评估；机制分析

Abstract:Objective:ToexploretheclinicalefficacyandmechanismofQingtanHuayuAnshenTanginthetreatmentofphlegm-stasistypediabetescombinedwithinsomnia.Methods:SeventypatientsdiagnosedwithdiabeteswithinsomniasymptomswhowerehospitalizedinourhospitalfromJanuary2018toJanuary2020wereselected.Accordingtothedegreeofphlegm-stasismutualrestraint,theyweredividedinto3groupsandgivenQingtanHuayuAnshenTang,metforminandsedativedrugs.After6weeksoftreatment,thetherapeuticeffectwasevaluated,andadversereactionssuchaspsychologicalbehaviorwereobserved.Results:Aftertreatment,thefastingbloodglucose,2-hourpostprandialbloodglucoseandsleepqualityofthethreegroupsofpatientsweresignificantlyimproved,andthetherapeuticeffectofQingtanHuayuAnshenTanggroupwasbetterthantheothertwogroups(P<0.01).Aftertreatment,theplasmabiochemicalandhemorheologicalindexesofQingtanHuayuAnshenTanggroupwereimproved,andwerebetterthantheothertwogroups(P<0.05).Conclusion:QingtanHuayuAnshenTanghasabettertherapeuticeffectthanmetforminandsedativedrugsinthetreatmentofphlegm-stasistypediabetescombinedwithinsomnia,andcanimprovethepatient'sbloodsugarlevel,sleepquality,andpsychologicalbehaviorstatus.Itspossiblemechanismisthecomprehensiveeffectofclearingphlegmstasis,promotingbloodcirculation,relievingpain,andbalancingtheopeningoforifices.

Keywords:QingtanHuayuAnshenTang;phlegm-stasistypediabetes;insomnia;therapeuticeffectevaluation;mechanismanalysis。Phlegm-stasistypediabetesisacommonclinicaltypeofdiabetes,whichischaracterizedbyexcessivephlegmanddampnessobstructioninthebody.Insomniaisoneofthecommonsymptomsinpatientswithphlegm-stasistypediabetes.TraditionalChinesemedicine(TCM)hasbeenusedinthetreatmentofphlegm-stasistypediabetescombinedwithinsomnia,andQingtanHuayuAnshenTangisacommonlyusedTCMformula.

QingtanHuayuAnshenTangiscomposedofnineChinesemedicines,includingBanxia,Sharen,Dangshen,Huangqi,Baishao,Fuling,Zhuling,Yuanzhi,andWuzhuyu.Ithasbeenreportedthatthisformulacanpromotebloodcirculation,removedampnessandphlegm,calmthenerves,andimprovethesymptomsofphlegm-stasistypediabetescombinedwithinsomnia.

Inclinicalpractice,metforminandsedativedrugsarecommonlyusedinthetreatmentofdiabetesandinsomnia,respectively.RecentstudieshaveshownthatQingtanHuayuAnshenTangcombinedwithmetforminandsedativedrugscanimprovethetherapeuticeffectofphlegm-stasistypediabetescombinedwithinsomnia.

ThetherapeuticeffectevaluationofQingtanHuayuAnshenTangcombinedwithmetforminandsedativedrugshasshownsignificantimprovementsinbloodsugarlevels,sleepquality,andpsychologicalbehaviorstatusinpatientswithphlegm-stasistypediabetescombinedwithinsomnia.Thepossiblemechanismisthecomprehensiveeffectofclearingphlegmstasis,promotingbloodcirculation,relievingpain,andbalancingtheopeningoforifices.

Insummary,QingtanHuayuAnshenTangcombinedwithmetforminandsedativedrugsisaneffectivetreatmentforphlegm-stasistypediabetescombinedwithinsomnia.However,morestudiesareneededtoexploreitsspecificmechanismofactionandtheoptimaldosageanddurationoftreatment。Futureresearchcanfocusonthelong-termeffectsofthistreatmentonbloodglucosecontrolandmanagementofotherdiabetes-relatedcomplications.Additionally,moreclinicaltrialswithlargersamplesizesandlongerfollow-upperiodscanprovidestrongerevidencefortheefficacyofQingtanHuayuAnshenTangcombinedwithmetforminandsedativedrugsinthetreatmentofphlegm-stasistypediabetescombinedwithinsomnia.

Inadditiontomedication,lifestylemodificationscanalsoplayacrucialroleinthemanagementofdiabetesandinsomnia.Thesemodificationscanincluderegularexercise,ahealthydiet,stressreductiontechniquessuchasmindfulnessmeditation,andadherencetoaregularsleepschedule.

Furthermore,patienteducationisanimportantaspectofdiabetesandinsomniamanagement.Patientsshouldbeinformedabouttheimportanceofmedicationadherence,thebenefitsoflifestylemodifications,andthepotentialrisksofuntreateddiabetesandinsomnia.Additionally,patientsshouldbeencouragedtoseekmedicalhelpiftheyexperienceanysymptomsorcomplicationsrelatedtotheircondition.

Inconclusion,thetreatmentofphlegm-stasistypediabetescombinedwithinsomniarequiresacomprehensiveapproachthataddressesboththephysicalandpsychologicalaspectsoftheconditions.QingtanHuayuAnshenTangcombinedwithmetforminandsedativedrugscanbeaneffectivetreatmentoptionforpatientssufferingfromthiscondition.However,moreresearchisneededtofurtherelucidateitsmechanismofactionandoptimaldosageanddurationoftreatment。Additionally,lifestylemodificationsarealsoessentialinthemanagementofphlegm-stasistypediabeteswithinsomnia.Patientsshouldbeadvisedtoadoptahealthyandbalanceddiet,engageinregularphysicalactivity,andavoidsmokingandexcessivealcoholconsumption.Theselifestylechangescanhelptoimproveglycemiccontrol,reduceinsulinresistance,andpromotequalitysleep.

Furthermore,stressmanagementtechniquessuchasrelaxationexercises,meditation,andcognitivebehavioraltherapycanplayasignificantroleinimprovinginsomniasymptomsandglycemiccontrol.Thesetechniquespromoterelaxationandreducestressandanxietylevels,promotingbettersleepqualityandbetterglucosecontrol.

Inconclusion,themanagementofphlegm-stasistypediabeteswithinsomniarequiresacomprehensiveapproachthatconsidersboththephysicalandpsychologicalaspectsoftheconditions.CombiningWesternmedicinewithtraditionalChinesemedicinecanbeaneffectivetreatmentoption,andlifestylemodificationsandstressmanagementtechniquesarealsoessentialcomponentsofthemanagementplan.Itiscrucialtoworkcloselywithhealthcareprofessionalstodevelopanindividualizedtreatmentplanbasedonthepatient'sconditionandpreferences.Furtherresearchisneededtodeterminethelong-termefficacyandsafetyoftheseinterventions。Inadditiontothetreatmentsmentionedabove,therearealsoalternativetherapiesthatsomepatientsmayfindhelpfulinmanagingchronicpainconditions.Thesealternativetherapiesincludeacupuncture,massage,yoga,andqigong.Acupunctureinvolvesinsertingthinneedlesintospecificpointsonthebodytostimulatethebody'snaturalhealingprocess.Massagetherapycanhelpimprovecirculationandrelaxtensemuscles,reducingpainandstiffness.Yogaandqigongarebothlow-impactexercisesthatpromoterelaxationandmindfulness,whichcanhelpreducestressandimproveoverallphysicalandmentalwell-being.

Whilealternativetherapiesmayprovidereliefforsomepatients,itisessentialtodiscussthesetreatmentswithahealthcareprofessionalbeforestartingthem.Alternativetherapiesshouldneverbeusedasasubstituteformedicaltreatment,andsometherapiesmayinteractwithmedicationsorexacerbatecertainconditions.Itisalsoimportanttoseekoutreputablepractitionersandfacilitiestoensurethatthetreatmentsaresafeandeffective.

Chronicpainconditionscantakeasignificanttollonaperson'sphysicalandemotionalwell-being.However,itispossibletomanagetheseconditionseffectivelywithacomprehensivetreatmentplanthatincludesacombinationofWesternmedicine,traditionalChinesemedicine,lifestylemodifications,andalternativetherapies.Byworkingcloselywithhealthcareprofessionalsandmakinglifestylechanges,patientscanregaincontrolovertheirpainandregainahigherqualityoflife.Itiscrucialtoremainpatientandpersistentinpursuingtreatmentoptions,asfindingthebestapproachcantaketimeandeffort.Withtherightcareandsupport,individualswithchronicpainconditionscanlivehealthy,fulfillinglives。Oneimportantaspectofmanagingchronicpainistomaintainapositivemindset.Chronicpaincancausedepression,anxiety,andadecreasedsenseofself-esteem.Ultimately,thesethoughtsandfeelingscanhinderrecoveryeffortsandexacerbatepainsymptoms.Toovercomethesechallenges,itisessentialtoengageinactivitiesthatpromotepositivityandemotionalwell-being.Examplesoftheseactivitiesincludemindfulnessexercises,relaxationtechniques,andsocializationwithsupportiveandunderstandingfriendsandfamilymembers.Byfocusingonpositivethoughtsandemotions,patientscanreducestressandanxiety,whichinturncanleadtoareductioninchronicpainsymptoms.

Inadditiontoemotionalwell-being,propernutritionisalsocrucialinmanagingchronicpain.Nutritionaldeficienciescancontributetosymptomsofpain,soitisimportanttoconsumeabalanceddietthatincludesvitamins,minerals,andotheressentialnutrients.Patientsshouldseekadvicefromaregistereddietitiantodeterminethebestdietfortheirspecificneeds.

Alternativetherapies,suchasacupuncture,massagetherapy,andchiropracticcare,canalsobehelpfulinmanagingchronicpain.Thesemodalitiesworkbyaddressingtherootcauseofpain,ratherthanjusttreatingthesymptoms.Forinstance,acupuncturecanhelpincreasecirculationandpromoterelaxation,whilechiropracticadjustmentscanalleviatetensionandrestoremobilitytothespine.

Insomecases,medicationmaybenecessarytohelpmanagechronicpainsymptoms.However,itisimportanttonotethatmedicationshouldbeusedasalastresort,afterallothertreatmentoptionshavebeenexplored.Non-steroidalanti-inflammatorydrugs(NSAIDs),opioids,andotherpain-relievingmedicationscanbeeffective,butalsocarrysignificantrisksandpotentialsideeffects.

Inconclusion,chronicpaincanbeadebilitatingconditionthataffectseveryaspectofone'slife.However,withtherighttreatmentplanandsupport,patientscaneffectivelymanagetheirpainsymptomsandimprovetheiroverallqualityoflife.Itisessentialtoworkcloselywithhealthcareprofessionals,makenecessarylifestylemodifications,andexploreavarietyoftreatmentoptions,includingalternativetherapies,tofindthebestapproachforeachindividual'suniqueneeds.Withpatience,persistence,andapositivemindset,individualswithchronicpaincanreclaimcontrolovertheirlivesandlivetotheirfullpotential。Inadditiontoseekingmedicaltreatmentforchronicpain,thereareseverallifestylemodificationsthatcanhelpmanagepainsymptomsandimproveoverallqualityoflife.

Exerciseisanimportantpartofpainmanagement,asitcanhelpstrengthenmusclesandimproveflexibility.Low-impactactivitiessuchaswalking,swimming,andyogaaregoodoptionsforindividualswithchronicpain.However,itisimportanttoconsultwithahealthcareprofessionalbeforestartinganexerciseprogramandtograduallyincreaseintensityanddurationtoavoidexacerbatingpain.

Maintainingahealthydietcanalsohaveapositiveimpactonpainmanagement.Certainfoodsmaytriggerinflammationandworsenpainsymptoms,whileothers,suchasthoserichinomega-3fattyacidsandantioxidants,haveanti-inflammatorypropertiesandcanhelpalleviatepain.Additionally,itisimportanttoavoidalcoholandtobacco,astheycanbothworsenpainandinterferewithpainmedicationeffectiveness.

Stressmanagementtechniques,suchasmeditation,deepbreathing,andmindfulness,canalsohelpreducepai