(1.1.1)中药化学发展史

ChemistryofTraditionalChineseMedicineChapterOne:Introduction1.HistoricalDevelopment2.ModernResearch3.FutureDevelopment4.Definition,ResearchObjectandResearchContent1.HistoricalDevelopment19201930194019501970ephedrine:stimulatesthecentralnervoussystem,constrictsbloodvessels,enhancesthesecretionofsweatglands,andrelievesthespasmofsmoothmuscles,etcrutin,digitalis,berberine,montane,vincristine,etctetrahydropalmatine,hydroquinoneandhydroquinoneallhaveanalgesiceffectHydroxycamptothecin-anticancerTrichosanthin–inducedlaborArtemisinin,artemether,dihydroartemisinin-antimalarialChemistryofTraditionalChineseMedicine--HistoricalResearchOverviewcucurbitine,Securinine,sinomenine,liensinine,shikoniwualkaloidA19602.ModernResearch

inrecentdecades500kindsoftraditionalChinesemedicinesarecommonlyusedTherearemorethan10,000compounds,includingmorethan600activeingredients(concentratedinlowpolaritycomponents).Morethan40kindsofnewdrugshavebeendevelopedSuchasartemisinin,ginsenosideRg3,toosendanin,etcResults&ApplicationsFocusonhighlypolarcompoundActivitytracing;Combinationofbiologicaltechniques;Holisticandcompoundsystematicresearch,“Combination"ChinesemedicineCurrentdiversificationChemistryofTraditionalChineseMedicine——Function

andSignificanceDrugsWesternMedicineNaturalMedicineTraditionalChineseMedicine？AhandfulofArtemisiacarvifoliaaresoakedintwolitersofwater,takeitsjuice,alldown.lowtemperatureextractionSavemillionsofmalariapatientsartemisinindilatecoronaryvesselsandimprovemyocardialischemiaeightkindsofdiosgeninandrographolideginkgolidepaclitaxelCuscohygrinumecgoninecolchicinecornocentinpilocarpingalanthaminereserpineberberinepuerarinbifendatatumChemistryofTraditionalChineseMedicine——Function

andSignificancedrugsfoodandhealthproducts腥reducebloodvesselbrittlenessandabnormal

permeability,preventarteriosclerosisJapan:foodadditivesDemand:nearlytenthousandtonsIndustry:“GhostFire"SoyIsoflavoneEstrogeniceffectChemistryofTraditionalChineseMedicine——Function

andSignificancedailynecessi-tiesdrugsfoodandhealthproductsGetridofthesmellAdjustthetastevolatilecomponentSpicesindustryHealthcareproductscosmeticsgeraniolnerolicitronellolmentholcamphorChemistryofTraditionalChineseMedicine——Function

andSignificancedailynecessi-tiesdrugsfoodandhealthproductsscientificpheno-menongrowthandchangecolorearlyflowering:lightyellowmidflowering:yellowlateflowering:redCarthamin(yellow)dihydroflavonesCarthamone（red）turngreenturnblackRawRehmanniaScutellariabaicalensisGeorgiprocessingDiscolorat-ion中药用法RadixAconitiandAconitilateralisradixPraeparataaredecoctedfirstandforalongtimePogostemonisherbaandAmomifructusrotundus

aredecoctedlater

TheprincipleofreducingtoxicityofdecoctingfirstanddecoctingforalongtimeforRadixAconitiandAconitilateralisradixpraeparataareusageofherbsaconitinebenzoylaconineaconine3.ThedevelopmentofChemistryofTraditionalChineseMedicineinthefuture

1）Searchingforeffectiveingredientsandleadcompoundstopreventandtreatdiseases.

2）GivingfullplaytothegreatadvantagesoftraditionalChinesemedicine

inhealthcare,andcarryingouttheresearchanddevelopmentofhealthfoodandfunctionalfood.

Anti-tumordrugs,cardio-cerebrovasculardrugs,diabetesdrugs,antiviraldrugs,senilediseasesdrugs.

functionalfood,naturalpigment,spice,cosmetic.3）UndertheguidanceofthecharacteristictheoriesoftraditionalChinesemedicine,wewillsortoutandexplorethetreasuresofChinesemedicine,suchasthematerialbasisofchinesemedicalprescriptio,thetheoreticalofmedicinalproperties,andtheprincipleofprocessing.3.ThedevelopmentofChemistryofTraditionalChineseMedicine

inthefuture4）Inadditiontofocusingonthecommoningredientsinplants,weshouldalsostrengthentheresearchonpolypeptides,polysaccharides,tanninsandmarineactiveingredients.Atthesametime,structure-activityrelationship,structuraltransformationandmodificationresearchshouldbestrengthened.3.ThedevelopmentofChemistryofTraditionalChineseMedicine

inthefuture5）ToestablishandimprovethequalitystandardsofChinesemedicinalmaterialsandChinesepatentmedicine.

6）ImprovethedosageformoftraditionalChinesemedicine,improvethequalityofmedicineandclinicalefficacy.

GoodAgriculturalPracticeforChineseCrudeDrugs（GAP）

GoodManufacturingPractice（GMP）"Threeeffects"(highefficiency,quickeffectandlongeffect)"Threesmall"(smalldose,smalltoxicity,smallsideeffects)"Threeconveniences"(easytostore,carryandtake)3.ThedevelopmentofChemistryofTraditionalChineseMedicine

inthefutureLonghistory,uniquetheoryTreatmentaccordingtosyndromedifferentiationMostChinesemedicineiscompoundandcompatibleCharacteristicsoftraditionalChinesemedicineNaturalmedicinetherangeiswide,thevarietyisnumerousfocusonmonomeractiveingred