TRAP-6-PAR-1-agonist-peptide-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETRAP-6Cat.No.:HY-P0078CASNo.:141136-83-6Synonyms:PAR-1agonistpeptide;ThrombinReceptorActivatorPeptide6分⼦式:C₃₄H₅₆N₁₀O₉分⼦量:748.87Sequence:Ser-Phe-Leu-Leu-Arg-AsnSequenceShortening:SFLLRN作⽤靶点:ProteaseActivatedReceptor(PAR)作⽤通路:GPCR/GProtein储存⽅式:Powder-80°C2years-20°C1yearInsolvent-80°C6months-20°C1month溶解性数据体外实验H2O:25mg/mL(33.38mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.3353mL6.6767mL13.3535mL5mM0.2671mL1.3353mL2.6707mL10mM0.1335mL0.6677mL1.3353mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性TRAP-6(PAR-1agonistpeptide)，⼀种多肽⽚段，选择性的蛋⽩酶激活受体1(PAR1)激动剂。TRAP-6通过1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE凝⾎酶受体激活⼈⾎⼩板。TRAP-6对PAR4⽆活性。IC50&TargetPAR1[1]体外研究TRAP-6(0.01-10μM)triggerscalciummobilizationinXenopusoocytesheterologouslyexpressingPAR1[1].TRAP-6(0.01-10μM;30min)activateshumanplatelets[1].TRAP-6(100μM)doesnotcausetheplateletsofrabbitsorratstochangeshape,aggregate,releasegranulecontents,orformthromboxane[2].体内研究TRAP(1mg/kg;i.v.)producesabiphasicresponseinbloodpressureininactin-anesthetizedrats[3].户使⽤本产品发表的科研⽂献•Phytomedicine.12June2022,154271.•MolMedRep.2019Jun;19(6):5291-5300.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].KahnML,et,al.Protease-activatedreceptors1and4mediateactivationofhumanplateletsbythrombin.JClinInvest.1999Mar;103(6):879-87.[2].Kinlough-RathboneRL,et,al.Rabbitandratplateletsdonotrespondtothrombinreceptorpeptidesthatactivatehumanplatelets.Blood.1993Jul1;82(1):103-6.[3].ChintalaMS,et,al.Disparateeffectsofthrombinreceptoractivatingpeptideonplateletsandperipheralvasculatureinrats.EurJPharmacol.1998May22;349(2-3):237-43.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: