CK-869-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECK-869Cat.No.:HY-16927CASNo.:388592-44-7分⼦式:C₁₇H₁₆BrNO₃S分⼦量:394.28作⽤靶点:Arp2/3Complex作⽤通路:Cytoskeleton储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:25mg/mL(63.41mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5363mL12.6813mL25.3627mL5mM0.5073mL2.5363mL5.0725mL10mM0.2536mL1.2681mL2.5363mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(6.34mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.34mM);Suspendedsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.34mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性CK-869肌动蛋⽩相关蛋⽩2/3复合体(ARP2/3)的抑制剂，其IC50值为7μM。IC50&TargetIC50:7μM(ARP2/3)[1].体外研究CK-869isanActin-RelatedProtein2/3(ARP2/3)complexinhibitor,withanIC50of7μM[1].CK-869significantlyinhibitsMTpolymerizationevenataconcentrationof25μM[2].户使⽤本产品发表的科研⽂献•CellRep.2021Jul6;36(1):109318.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].HetrickB,etal.SmallmoleculesCK-666andCK-869inhibitactin-relatedprotein2/3complexbyblockinganactivatingconformationalchange.ChemBiol.2013May23;20(5):701-12.[2].YamagishiY,etal.UseofCK-548andCK-869asArp2/3complexinhibitorsdirectlysuppressesmicrotubuleassemblybothinvitroandinvivo.BiochemBiophysResCommun.2018Feb12;496(3):834-839.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400