Zidebactam-WCK-5107-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEZidebactamCat.No.:HY-120859CASNo.:1436861-97-0Synonyms:WCK-5107分⼦式:C₁₃H₂₁N₅O₇S分⼦量:391.4作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(638.73mM;Needultrasonic)H2O:50mg/mL(127.75mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5549mL12.7747mL25.5493mL5mM0.5110mL2.5549mL5.1099mL10mM0.2555mL1.2775mL2.5549mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1.98mg/mL(5.06mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(5.31mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(5.31mM);Clearsolution4.请依序添加每种溶剂：PBSSolubility:100mg/mL(255.49mM);Clearsolution;Needultrasonicandwarmingandheatto60°CBIOLOGICALACTIVITY⽣物活性Zidebactam(WCK-5107)⼀种有效的β-内酰胺酶抑制剂[1]。Zidebactam也⼀种霉素结合蛋⽩2(PBP2)抑制剂，其IC50为0.26μg/ml[2]。IC50&TargetIC50:0.26μg/mL(P.aeruginosaPAO1PBP2)[2]体外研究Zidebactam(WCK-5107)inhibitsWTEnterobacteriaceaewithaMIC50of0.25ꢀmg/L.ZidebactamaloneexhibitsvariableactivitywhentestedagainstE.coli(MIC50/900.12/0.12ꢀmg/L)andEnterobacterspp.(MIC50/900.12/0.25ꢀmg/L)[1].户使⽤本产品发表的科研⽂献•MicrobiolSpectr.2022Feb23;10(1):e0267821.•AntimicrobAgentsChemother.2021Nov22;AAC0167621.•Antibiotics(Basel).2021,10(11),1341.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SaderHS,etal.WCK5222(cefepime/zidebactam)antimicrobialactivitytestedagainstGram-negativeorganismsproducingclinicallyrelevantβ-lactamases.JAntimicrobChemother.2017Jun1;72(6):1696-1703.[2].MoyaB,etal.WCK5107(Zidebactam)andWCK5153AreNovelInhibitorsofPBP2ShowingPotent"β-LactamEnhancer"ActivityagainstPseudomonasaeruginosa,IncludingMultidrug-ResistantMetallo-β-Lactamase-ProducingHigh-RiskClones.AntimicrobAgentsChemMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forr