Elexacaftor-VX-445-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEElexacaftorCat.No.:HY-111772CASNo.:2216712-66-0Synonyms:VX-445分⼦式:C₂₆H₃₄F₃N₇O₄S分⼦量:597.65作⽤靶点:CFTR;Autophagy作⽤通路:MembraneTransporter/IonChannel;Autophagy储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:125mg/mL(209.15mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.6732mL8.3661mL16.7322mL5mM0.3346mL1.6732mL3.3464mL10mM0.1673mL0.8366mL1.6732mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.08mg/mL(3.48mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(3.48mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Elexacaftor(VX-445,Compound1)⼀种囊性纤维化跨膜电导调节因⼦(CFTR)校正剂。Elexacaftor(VX-445,Compound1)促进CFTR的加⼯和转运，增加细胞表CFTR的数量。IC50&TargetCFTR[1].体外研究Elexacaftor(VX-445)isanext-generationcysticfibrosistransmembraneconductanceregulator(CFTR)correctordesignedtorestorePhe508delCFTRproteinfunction.Elexacaftor(VX-445)hasthepotentialtotreatcysticfibrosis.VX-445-Tezacaftor-VX-770significantlyimprovesPhe508delCFTRproteinprocessing,trafficking,andchloridetransporttoagreaterextentthananytwooftheseagentsindualcombination[2].户使⽤本产品发表的科研⽂献•AmJRespirCritCareMed.2021Aug11.•JClinInvest.2021Aug16;131(16):e150398.•JCIInsight.2020Sep17;5(18):e139983.•IntJMolSci.2022,23(1),24.•IntJMolSci.2021,22(6),3063.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].AlexanderRussellAbela,etal.MODULATOROFTHECYSTICFIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR,PHARMACEUTICALCOMPOSITIONS,METHODSOFTREATMENT,ANDPROCESSFORMAKINGTHEMODULATOR.US20180162839A1.[2].KeatingD,etal.VX-445-Tezacaftor-VX-770inPatientswithCysticFibrosisandOneorTwoPhe508delAlleles.NEnglJMed.2018Oct25;379(17):1612-1620.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresear