Ceftobiprole-Ro-63-9141-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECeftobiproleCat.No.:HY-112579CASNo.:209467-52-7Synonyms:Ro63-9141;BAL9141分⼦式:C₂₀H₂₂N₈O₆S₂分⼦量:534.57作⽤靶点:Bacterial;Antibiotic作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2years*该产品在溶液状态不稳定，建议您现⽤现配，即刻使⽤。溶解性数据体外实验DMSO:4.95mg/mL(9.26mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.8707mL9.3533mL18.7066mL5mM0.3741mL1.8707mL3.7413mL10mM---------请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现⽤现配，即刻使⽤.体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥0.5mg/mL(0.94mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥0.5mg/mL(0.94mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥0.5mg/mL(0.94mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Ceftobiprole(Ro63-9141)⼀种⼴谱头孢素，对甲氧西林(MRSA)、耐万古霉素葡萄球(VRSA)和耐霉素链球具有⾼⽔平的体外活性，对MRSA的MIC90值为2μg/mL。Ceftobiprole还抑制⾰兰⽒阳性和⾰兰⽒性病原体。IC50&Targetβ-lactam体外研究Ceftobiprole(Ro63-9141)hasdemonstratesactivityagainstimportantgram-positivebacteria,includingS.pneumonia(PRSP),Methicillin-resistantS.aureus(MRSA),andE.faecaliswithMIC90valuesof0.25,2,and2mcg/mL,respectively.Ceftobiprolehasalsodemonstratedpotentinvitroactivityagainstseveralclinicalisolatesofcommunity-associatedMethicillin-resistantS.aureus(CA-MRSA),S.aureus(VISA),andS.aureus(VRSA),withaminimuminhibitoryconcentration(MIC)of2mcg/mL[1].CeftobiproleishighlyactiveagainstS.aureus,withMICsrangingfrom0.12to4mg/L(onlyoneresistantstrain,MICof4mg/L).Furthermore,CeftobiproleistwicemoreactiveonMethicillin-susceptibleS.aureus(MSSA)strainswithMIC50andMIC90of0.5mg/LthanonMRSAstrainswithMIC50andMIC90of1mg/L.Moreover,Panton-Valentineleukocidin(PVL)+MRSAareslightlymoresusceptibletoCeftobiprole(MIC50of0.5mg/LandMIC90of1mg/L)thanPVL-MRSA(MIC50andMIC90of1mg/L)[2].户使⽤本产品发表的科研⽂献•Antibiotics(Basel).2022,11(10),1351.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].EAzoulay-Dupuis,etal.EfficacyofBAL5788,aprodrugofcephalosporinBAL9141,inamousemodelofacutepneumococcalpneumonia.AntimicrobAgentsChemother.2004Apr;48(4):1105-11.[2].KisgenJ,etal.Ceftobiprole,aBroad-SpectrumCephalosporinWithActivityagainstMethicillin-ResistantStaphylococcusaureus(MRSA).PT.2008Nov;33(11):631-41.[3].HodilleE,etal.Invitroactivityofceftobiproleon440Staphylococcusaureusstrainsisolatedfrombronchopulmonaryinfections.MedMalInfect.2017Mar;47(2):152-157.McePdfHeightCaution:Producthasnotbeenfullyvalidatedform