FT-1518-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFT-1518Cat.No.:HY-107363CASNo.:1313026-58-2分⼦式:C₂₀H₂₆N₈O分⼦量:394.47作⽤靶点:mTOR作⽤通路:PI3K/Akt/mTOR储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:5mg/mL(12.68mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5350mL12.6752mL25.3505mL5mM0.5070mL2.5350mL5.0701mL10mM0.2535mL1.2675mL2.5350mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥0.5mg/mL(1.27mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥0.5mg/mL(1.27mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥0.5mg/mL(1.27mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性FT-1518⼀种选择性的，可⼝服的，有效的新⼀代mTORC1和mTORC2抑制剂，具有抗肿瘤的活性。IC50&TargetmTORC1mTORC2体外研究FT-1518isanewgenerationselective,potentandoralbioavailablemTORC1andmTORC2inhibitor,andexhibitsantitumoractivity.FT-1518displayssignificantgrowthinhibitoryactivityagainstalargepanelofhematologicandsolidtumorcelllineswithmostactivitiesfallingintolownanomolarrange.FT-1518cuasespotentinhibitionofthemTORpathwaybiomarkers(mTORC1&2biomarkers[pAkt(S473)andpS6(S240/244)orp70S6K),noinhibitionofPI3Kbiomarker[pAkt(T308)]incells[1].体内研究FT-1518exhibitsdose-dependentandhighertumorgrowthinhibition(TGI)inmultiplesolidtumorxenografts[1].REFERENCES[1].AlainC.Mita,etal.Abstract137:FT-1518,anewgenerationselectiveandpotentmTORC1andmTORC2inhibitor:aninvitroandinvivoprofile.CancerRes2017;77(13Suppl).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te