MRS1845-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMRS1845Cat.No.:HY-103310CASNo.:544478-19-5分⼦式:C₂₁H₂₂N₂O₆分⼦量:398.41作⽤靶点:CalciumChannel;CRACChannel作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:≥83.33mg/mL(209.16mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5100mL12.5499mL25.0998mL5mM0.5020mL2.5100mL5.0200mL10mM0.2510mL1.2550mL2.5100mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥5mg/mL(12.55mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥5mg/mL(12.55mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥5mg/mL(12.55mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性MRS1845⼀种选择性钙池调控钙离⼦通道(SOC)抑制剂，IC50为1.7μM[1]。MRS1845⼀种ORAI1抑制剂[2][3]。IC50&TargetCa2+channel[1]体外研究TreatmentwithMRS1845(10μM)virtuallydisruptstheeffectsofβ-glycerophosphateonstore-operatedCa2+entry(SOCE)[2].MRS1845(10μM)significantlydecreasesSOCEandvirtuallyabolishestheincreaseofSOCEfollowingplacentalgrowthfactor(PlGF)treatment[3].REFERENCES[1].HarperJL,etal.DihydropyridinesasinhibitorsofcapacitativecalciumentryinleukemicHL-60cells.BiochemPharmacol.2003Feb1;65(3):329-38.[2].MaK,etal.Phosphate-inducedORAI1expressionandstore-operatedCaentryinaorticsmoothmusclecells.JMolMed(Berl).2019Oct;97(10):1465-1475.[3].AbdelazeemKNM,etal.UpregulationofOrai1andSTIM1expressionaswellasstore-operatedCaentryinovarycarcinomacellsbyplacentalgrowthfactor.BiochemBiophysResCommun.2019May7;512(3):467-472.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseon