KDU731-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEKDU731Cat.No.:HY-103583CASNo.:1610610-48-4分⼦式:C₂₂H₁₆N₆O₂分⼦量:396.4作⽤靶点:PI4K;Parasite作⽤通路:PI3K/Akt/mTOR;Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:83.33mg/mL(210.22mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.5227mL12.6135mL25.2270mL5mM0.5045mL2.5227mL5.0454mL10mM0.2523mL1.2614mL2.5227mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性KDU731，具有⼝服活性的C.parvumPI4K抑制剂，阻断体内外隐孢⼦⾍感染，IC50值为25nM。KDU731是研究隐孢⼦⾍引起的腹泻的有望候选药物，具有⼴泛的安全性。IC50&TargetPI4K1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE体内研究KDU731(orallyadministration;7or10mg/kg;16days)haspotentactivityagainstCryptosporidiuminimmunocompromisedIFN-γKOmiceanddramaticallyreducesoocystshedding[2].KDU731(orallyadministration;5mg/kg;every12hoursfor7days)istoleratedinallcalves,andtreatedcalvesshedsignificantlyfeweroocyststhanvehicletreatedcalvesintheirstool[2].AnimalModel:6-8weekoldC57BL/6IFN-γ-knockoutmicewith10,000oocysts[1]Dosage:7or10mg/kgAdministration:Orallyadministration;7or10mg/kg;16daysResult:Resultedinsignificantreductionofoocystshedding.AnimalModel:Neonatalcalveswith5x107oocysts[1]Dosage:5mg/kgAdministration:Orallyadministration;5mg/kg;every12hoursfor7daysResult:Resultedinsignificantreductionofoocystsheddingintreatedcalvesintheirstool.REFERENCES[1].WardHD,etal.NewToolsforCryptosporidiumLeadtoNewHopeforCryptosporidiosis.TrendsParasitol.2017Sep;33(9):662-664.[2].ManjunathaUH,etal.ACryptosporidiumPI(4)Kinhibitorisadrugcandidateforcryptosporidiosis.Nature.2017Jun15;546(7658):376-380.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-