Antimicrobial-agent-5-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAntimicrobialagent-5Cat.No.:HY-151399分⼦式:C₃₂H₄₈N₁₆分⼦量:656.83作⽤靶点:Bacterial作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Antimicrobialagent-5⼀种强效抗剂，对⾰兰⽒阳性/性都具有良好的细胞选择性。Antimicrobialagent-5能够阻断LPS和CD14/TLR4受体间的相互作⽤，表现出抗炎活性并缓解LPS诱导的炎症。体外研究Antimicrobialagent-5(compound9)(0.5-32μg/mL,16h;1-128μg/mL;24h)showspotentbiofilminhibitory(IC50=2μg/mL)anderadicatingactivities(IC50=16μg/mL)againstmultidrug-resistantPseudomonasaeruginosa(MDRPA)[1].Antimicrobialagent-5(5μgmL,20μg/mL;18h)inhibitsboththereleaseandexpressionofnitricoxide(NO)andtumornecrosisfactor-α(TNF-α)fromLPS-stimulated(1μg/mL)RAW264.7cells[1].Antimicrobialagent-5exhibitsproteolyticresistanceandsalt/serumstability[1].Antimicrobialagent-5(0.5-256μg/mL;2h)exhibitsnegligiblesideeffectsagainstsheepredbloodcells(sRBCs)withhemolyticactivity(theminimumhemolyticconcentration,MHC)of>256μg/mL[1].CellViabilityAssay[1]CellLine:RAW264.7cellsConcentration:5μgmL,20μg/mLIncubationTime:18hoursResult:DecreasedTNF-αreleaseat20μg/mL,withinhibitionrateof72.44%.ResultsreductionintheLPS-stimulatedproductionofNO,withinhibitionrateof31.51%.CellViabilityAssay[1]1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECellLine:E.coli[KCTC1682],P.aeruginosa[KCTC1637],S.epidermidis[KCTC1917],S.aureus[KCTC1621]Concentration:1-128μg/mLIncubationTime:24hoursResult:InhibitedGram-negativebacteriaandGram-positivebacteriawithIC50of6.1μM(E.coli[KCTC1682],P.aeruginosa[KCTC1637],S.epidermidis[KCTC1917],S.aureus[KCTC1621]),respectively.REFERENCES[1].DineshKumarS,etal.Cationic,amphipathicsmallmoleculesbasedonatriazine-piperazine-triazinescaffoldasanewclassofantimicrobialagents.EurJMedChem.2022Sep8;243:114747.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: