Shishijimicin-A-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEShishijimicinACat.No.:HY-N10537CASNo.:503860-50-2分⼦式:C₄₆H₅₂N₄O₁₂S₄分⼦量:981.18作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性ShishijimicinA⼀种新型的抗肿瘤剂，它从⼦囊Didemnumproliferum中发现的。ShishijimicinA表现出抗肿瘤活性，具有⾼度的细胞毒性。体外研究ShishijimicinA(compound1)(0.47-2.0pg/mL)showshighcytotoxicityfor3Y1,HelaandP388cells[1].ShishijimicinA(0.13-1000nM)showshighcytotoxicityforMESSA,MESSADXandHEK293Tcells[2].CellCytotoxicityAssay[1]CellLine:3Y1,HelaandP388cellsConcentration:0.47-2.0pg/mLIncubationTime:Result:ShowedIC50valuesof2.0,1.8,and0.47pg/mLfor3Y1,HelaandP388cells,respectively.CellCytotoxicityAssay[2]CellLine:MESSA,MESSADXandHEK293TcellsConcentration:0.13-1000nMIncubationTime:Result:ShowedIC50valuesof0.13,>1000,and0.016nMforMESSA,MESSADXandHEK1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE293Tcells,respectively.REFERENCES[1].NaoyaOku,etal.ShishijimicinsA-C,novelenediyneantitumorantibioticsfromtheascidianDidemnumproliferum(1).JAmChemSoc.2003Feb26;125(8):2044-5.[2].KCNicolaou,etal.StreamlinedTotalSynthesisofShishijimicinAandItsApplicationtotheDesign,Synthesis,andBiologicalEvaluationofAnaloguesthereofandPracticalSynthesesofPhthNSSMeandRelatedSulfenylatingReagents.JAmChemSoc.2018Sep26;140(38):12120-12136.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955