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FromCinderellatoPrincess-beyondmanuscriptDearEditor:Iamwritingtosubmitamanuscript,entitled“………”,toyourprestigiousjournal.…….E-mail:paper@theivy; TelearDr.Miczek:Weintendtopublishourpaper,entitled“………”,inNeuropsychopharmacogy.……E-mail:paper@theivy; TelournalSelectionimpactfactorvs.penetrationE-mail:paper@theivy; Tel:021-613901101）多巴胺4型受体在多动症模型上调E-mail:paper@theivy; Tel:021-613901101）多巴胺4型受体在多动症模型上调2）多巴胺4型受体拮抗剂减轻多动症状E-mail:paper@theivy; TelopamineD4receptorsinmotorhyperactivityinducedbyneonatal6-hydroxydopaminelesionsinrats

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BehavioralNeuroscience

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杂志领域-----------------------------------------------------------------PNAS 包罗万象JournalofNeuroscience 神经科学（基础）----------------------------------------------------------------------------E-mail:paper@theivy; TelopamineD4receptorsinmotorhyperactivityinducedbyneonatal6-hydroxydopaminelesionsinrats

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杂志领域-----------------------------------------------------------------PNAS 包罗万象JournalofNeuroscience 神经科学（基础）Neuropsychopharmacology 神经精神药理（临床、基础）----------------------------------------------------------------------------E-mail:paper@theivy; TelopamineD4receptorsinmotorhyperactivityinducedbyneonatal6-hydroxydopaminelesionsinrats

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杂志领域-----------------------------------------------------------------PNAS 包罗万象JournalofNeuroscience 神经科学（基础）Neuropsychopharmacology 神经精神药理（临床、基础）

BehavioralNeuroscience

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穿透力-----------------------------------------------------------------PNAS 差JournalofNeuroscience 偏Neuropsychopharmacology 强----------------------------------------------------------------------------E-mail:paper@theivy; TelopamineD4receptorsinmotorhyperactivityinducedbyneonatal6-hydroxydopaminelesionsinrats

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＋＋＋＋JournalofNeuroscience ＋＋

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BehavioralNeuroscience

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＋----------------------------------------------------------------------------E-mail:paper@theivy; TelhangK,TaraziFI,BaldessariniRJ:RoleofdopamineD4receptorsinmotorhyperactivityinducedbyneonatal6-hydroxydopaminelesionsinrats.Neuropsychopharmacology,25:624–632,2001ZhangK,TaraziFI,DavidsE,BaldessariniRJ:PlasticityofdopamineD4receptorsinratforebrain:Temporalassociationwithmotorhyperactivityfollowingneonatal6-hydroxydopaminelesioning.

Neuropsychopharmacology,26:625–633,2002E-mail:paper@theivy; TelhangK,TaraziFI,BaldessariniRJ:RoleofdopamineD4receptorsinmotorhyperactivityinducedbyneonatal6-hydroxydopaminelesionsinrats.Neuropsychopharmacology,25:624–632,2001ZhangK,TaraziFI,DavidsE,BaldessariniRJ:PlasticityofdopamineD4receptorsinratforebrain:Temporalassociationwithmotorhyperactivityfollowingneonatal6-hydroxydopaminelesioning.

Neuropsychopharmacology,26:625–633,2002ZhangK,GradyCJ,TsapakisEM,AndersenSL,TaraziFI,BaldessariniRJ:RegulationofworkingmemorybydopamineD4receptorinrats.Neuropsychopharmacology,29:1637–1647,2004E-mail:paper@theivy; TelearDr.Zhang:IamwritingthislettertoinviteyoutojointhePharmacologyforNeuropsychiatricDisordersSmallBusinessstudysectionoftheNationalInstitutesofHealth.Yourexpertisewouldbemosthelpfulindoingafairandobjectivereviewofthegrantapplications.……JeromeR.Wujek,PhDScientificReviewAdministratorNationalInstitutesofHealthCenterforScientificReviewE-mail:paper@theivy; Telowtorespondtoreviewercomments-theartof“butterup”E-mail:paper@theivy; Televiewer:TheD4receptorassayisinvalid.Theradioligand[3H]nemonapridelabelsallmembersoftheD2-likereceptors,includingtheD2,D3,andD4receptors.Admittedly,theauthorsmadeanattmpttooccludebindingof[3H]nemonapridetoD2andD3receptorswithraclopride.However,theD2receptorisfarmoreabundantthantheD4receptor.Asaresult,theclaimthatthisisaD4receptorassayisinvalid.

E-mail:paper@theivy; Teleunderstandthereviewerconcern.TheD2receptorisindeedfarmoreabundantthantheD4receptorinratbrain(roughly100fold;ref#1).Wedid,however,carriedoutacarefullydesignedexperimentinpurifiedreceptorsanddemonstratedthatat300nM(theconcentrationusedinourassay),racloprideeliminates>99.9%ofthebindingof[3H]nemonapridetoD2receptorwithoutaffect