Naphazoline-Naphthazoline-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENaphazolineCat.No.:HY-111326CASNo.:835-31-4Synonyms:Naphthazoline分⼦式:C₁₄H₁₄N₂分⼦量:210.27作⽤靶点:AdrenergicReceptor;TNFReceptor;InterleukinRelated;VEGFR作⽤通路:GPCR/GProtein;NeuronalSignaling;Apoptosis;Immunology/Inflammation;ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Naphazoline(Naphthazoline)⼀种有效的α-肾上腺素能受体(α-adrenergicreceptor)激动剂。Naphazoline能降低⾎管通透性和促进⾎管收缩。Naphazoline可降低炎症因⼦(TNF-α、IL-1β和IL-6)、细胞因⼦(IFN-γ和IL-4)、IgE、GMCSF和NGF的⽔平。Naphazoline可⽤于⾮细性结膜炎的研究。IC50&TargetIL-1βIL-6IL-4体内研究Naphazoline(0.2mg/kg,10µlpereye;IP,once)reduceshistamineorantigen-inducedconjunctivalvascularhyperpermeabilityinmice,andreducesconjunctivitisinmiceviaeffectsoninflammation,NGFandVEGF[1].AnimalModel:Femalewild-typeBALB/cmice(4-5weeks,18±2g,n=8/group,allergicconjunctivitismousemodelestablishedusinghistamineoranantigen(ovalbumin))[1]Dosage:0.2mg/mL,10µlpereyeAdministration:Intraperitonealinjection(IP),onceResult:inigfitljuticulajuertiit.duindicflaithtoiseaintiosighenlevelsofIL-1β,IL-6,IFN-γ,andIL-4.ReducedthelevelsofIgE,GMCSF,NGFandVEGFinantigen-inducedconjunctivalvascularhyperpermeabilitymice.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEREFERENCES[1].QuanL,et,al.Treatmentwitholopatadineandnaphazolinehydrochloridereducesallergicconjunctivitisinmicethroughalterationsininflammation,NGFandVEGF.MolMedRep.2016Apr;13(4):3319-25.[2].YamaguchiI,et,al.Centralandperipheraladrenergicmechanismsregulatinggastricsecretionintherat.JPharmacolExpTher.1977Oct;203(1):125-31.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37