Cefazolin-sodium-pentahydrate-Cephazolin-sodium-pentahydrate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECefazolinsodiumpentahydrateCat.No.:HY-B0756CASNo.:115850-11-8Synonyms:Cephazolinsodiumpentahydrate分⼦式:C₁₄H₂₃N₈NaO₉S₃分⼦量:566.57作⽤靶点:Antibiotic;Bacterial作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Cefazolinsodiumpentahydrate第⼀代头孢素类抗⽣素，可⽤于多种细感染的研究。Cefazolinsodiumpentahydrate具有抗炎作⽤，可以减轻术后认知功能障碍(POCD)。体外研究Cefazolinsodiumpentahydrate(0-300μg/ml;6or24h)hasadirectanti-inflammatoryeffectonC8-B4cellsstimulatedbylipopolysaccharide[2].Cefazolinsodiumpentahydrate(0-400μM;72h)treatmentinhibitsIL-2,IL-4andIL-15-inducedcellproliferation[3].Cefazolinsodiumpentahydrate(0-400μM;30min)treatmentinhibitsIL-2,IL-4,IL-15andIL-21-stimulatedJAK3phosphorylation[3].CellViabilityAssay[2]CellLine:C8-B4cellsConcentration:0,50,100,150,200,250,or300μg/mlIncubationTime:6or24hoursResult:InhibitedtheincreaseofIL-1βatalldoses,butinhibitedtheincreaseofIL-6onlyat200μg/ml.CellProliferationAssay[3]1/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECellLine:PBMC,andTF-1cellsConcentration:0,100,200,and400μMIncubationTime:72hoursResult:ReducedIL-2,IL-4andIL-15-inducedcellproliferation,suggestedthatCefazolininterferesnotonlywithIL-15Rα,butalsowithIL-2/IL-15Rβand/orγc.WesternBlotAnalysis[3]CellLine:PBMC,NK-92,andTF-1cellsConcentration:0,100,200,and400μMIncubationTime:30minResult:DiminishedthephosphorylationofJAK3inresponsetothecytokinetreatment,concludedsuppressingsignaltransductionbyγcreceptors.体内研究Cefazolinsodiumpentahydrate(Subcutaneousinjection;300-500mg/kg;oncedaily;5d)treatmentimproveslearningandmemoryinmiceaftersurgery[2].AnimalModel:6-to8-week-oldmaleCD-1miceunderwentclinicalexploratorylaparotomy[2]Dosage:300-500mg/kgAdministration:Subcutaneousinjection;300-500mg/kg;oncedaily;5daysResult:Attenuatedlearningandmemorydysfunctioninducedbythesurgery.户使⽤本产品发表的科研⽂献•NatCommun.2022Mar2;13(1):1116.•iScience.5January2022,103731.•FrontAgingNeurosci.Oct13,2021.•FrontAgingNeurosci.2021Oct13;13:748637.•ACSOmega.March3,2022.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].RQuintiliani,etal.Cefazolin.AnnInternMed.1978Nov;89(5Pt1):650-6.2/3MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[2].PengLiang,etal.Perioperativeuseofcefazolinamelioratespostoperativecognitivedysfunctionbutinducesgutinflammationinmice.JNeuroinflammation.2018Aug22;15(1):235.[3].BarbaraŻyżyńska-Granica,etal.Theanti-inflammatorypotentialofcefazolinascommongammachaincytokineinhibitor.SciRep.2020Feb19;10(1):2886.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedi