Menthofuran-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMenthofuranCat.No.:HY-N9484CASNo.:494-90-6分⼦式:C₁₀H₁₄O分⼦量:150.22作⽤靶点:DrugMetabolite作⽤通路:MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验氘代氯仿:125mg/mL(832.11mM;Needultrasonic)DMSO:100mg/mL(665.69mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM6.6569mL33.2845mL66.5690mL5mM1.3314mL6.6569mL13.3138mL10mM0.6657mL3.3285mL6.6569mL体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(16.64mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(16.64mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(16.64mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性Menthofuran(R)-(+)-Pulegone的毒性代谢物。Menthofuran通过控制下游单萜还原酶来调控薄荷精油的⽣物合成。REFERENCES[1].GordonWP,etal.Themetabolismoftheabortifacientterpene,(R)-(+)-pulegone,toaproximatetoxin,menthofuran.DrugMetabDispos.1987Sep-Oct;15(5):589-94.[2].MahmoudSS,etal.Menthofuranregulatesessentialoilbiosynthesisinpeppermintbycontrollingadownstreammonoterpenereductase.ProcNatlAcadSciUSA.2003Nov25;100(24):14481-6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955