化学结构图课件

ABCD152019211114181716432911012813765激素的结构及特点ABCD152019211114181716432911011醋酸氢化考的松(Hydrocortisoneacetate)OCH2OCOCH2OHOHOC醋酸氢化考的松(Hydrocortisoneacetate2醋酸氟氢考的松(Fludrocortisoneacetate)FOHOCH2OCOCH3OHOC醋酸氟氢考的松(Fludrocortisoneacetat3曲安奈德(Triamcinoloneacetonide.Kenelog)FOHOCH2OCOCH3OCOOCCH3CH3曲安奈德(Triamcinoloneacetonide.Ke4氟美松(Dexamethasone)FOCH2OHOCOHCH3HO氟美松(Dexamethasone)FOCH2OHOCOHC5肤轻松(醋酸仙乃乐，Fluocinonide)FOFCH2—OCOCH3OCHOOOCCH3CH3肤轻松(醋酸仙乃乐，Fluocinonide)FOFCH2—6丙酸氟替卡松丙酸氟替卡松7丙酸氟替卡松乳膏OFFHOCH3COSCH2FCH3OCOC2H5CH3HH丙酸氟替卡松乳膏OFFHOCH3COSCH2FCH3OCOC8倍他米松戊酸脂FOCH2OHOCHOO-C(CH2)3CH3OCH3倍他米松戊酸脂FOCH2OHOCHOO-C(CH2)3CH39氯氟舒松(Halcinonide)FOHOCH2CLOCOOCCH3CH3氯氟舒松(Halcinonide)FOHOCH2CLOCOO10氯倍他索丙酸酯(Clobetasol17-propionate)FOHOCH2CLOCOCOC2H3CH3氯倍他索丙酸酯(Clobetasol17-propiona11卤关他松(Halomethasonemonohydric，Sicorten)FOHOCH2OHOCCH3H2OCLF卤关他松(Halomethasonemonohydric，12卤倍他索丙酸酯(HalobetasolPropionate)FOHOCH2CLOCOCOC2H3CH3F卤倍他索丙酸酯(HalobetasolPropionate13双醋二氟松(Psorcon，索康)FOCH2OC—CH3OCOC—CH3CH3FO双醋二氟松(Psorcon，索康)FOCH2OC—CH3OC1417a丁酸酯氢化考的松(Hydrocortisone17-butyrate)OCH2OHOCO-C(CH2)2CH3HOO17a丁酸酯氢化考的松(Hydrocortisone1715地奈德(desonide)OOHOOHOCH3HHHOCH3CH3CH3地奈德(desonide)OOHOOHOCH3HHHOCH316糠酸莫米松(Mometasonefruoate)CLOHOCH2CLOCCH3OCO糠酸莫米松(Mometasonefruoate)CLOHO17OHOCH2OHOCOH16916cortisolOHOCH2OHOCOH16916cortisol18FOHOOCOFluticasonePropionateFSFH2CCOC2H1CH3FOHOOCOFluticasonePropionateF19FOHOOCOInactivecarboxylicacidderivateFCOC2H3CH3HOFOHOOCOInactivecarboxylicaci20泼尼松龙泼尼松龙21身体部分治疗区域一次所需药物的指尖单位量（无性别差异）头和颈躯干（前）躯干（后）手臂手脚腿4.5773162身体部分治疗区域一次所需头和颈躯干（前）手臂手脚腿4.57322

图1.考的索分子结构，FP及其无活性代谢产物。在1，6，9位的结构修饰加强了抗炎和盐皮质激素的活性。两个酯化天然结构大大提高了FP天然亲脂性和药物利用。快速代谢为非活性产物一半归因于取代的硫化酯解离，一半为17羧酸代谢产物带来的低系统活性。图1.考的索分子结构，FP及其无活性代谢产物23ABCD152019211114181716432911012813765激素的结构及特点ABCD1520192111141817164329110124醋酸氢化考的松(Hydrocortisoneacetate)OCH2OCOCH2OHOHOC醋酸氢化考的松(Hydrocortisoneacetate25醋酸氟氢考的松(Fludrocortisoneacetate)FOHOCH2OCOCH3OHOC醋酸氟氢考的松(Fludrocortisoneacetat26曲安奈德(Triamcinoloneacetonide.Kenelog)FOHOCH2OCOCH3OCOOCCH3CH3曲安奈德(Triamcinoloneacetonide.Ke27氟美松(Dexamethasone)FOCH2OHOCOHCH3HO氟美松(Dexamethasone)FOCH2OHOCOHC28肤轻松(醋酸仙乃乐，Fluocinonide)FOFCH2—OCOCH3OCHOOOCCH3CH3肤轻松(醋酸仙乃乐，Fluocinonide)FOFCH2—29丙酸氟替卡松丙酸氟替卡松30丙酸氟替卡松乳膏OFFHOCH3COSCH2FCH3OCOC2H5CH3HH丙酸氟替卡松乳膏OFFHOCH3COSCH2FCH3OCOC31倍他米松戊酸脂FOCH2OHOCHOO-C(CH2)3CH3OCH3倍他米松戊酸脂FOCH2OHOCHOO-C(CH2)3CH332氯氟舒松(Halcinonide)FOHOCH2CLOCOOCCH3CH3氯氟舒松(Halcinonide)FOHOCH2CLOCOO33氯倍他索丙酸酯(Clobetasol17-propionate)FOHOCH2CLOCOCOC2H3CH3氯倍他索丙酸酯(Clobetasol17-propiona34卤关他松(Halomethasonemonohydric，Sicorten)FOHOCH2OHOCCH3H2OCLF卤关他松(Halomethasonemonohydric，35卤倍他索丙酸酯(HalobetasolPropionate)FOHOCH2CLOCOCOC2H3CH3F卤倍他索丙酸酯(HalobetasolPropionate36双醋二氟松(Psorcon，索康)FOCH2OC—CH3OCOC—CH3CH3FO双醋二氟松(Psorcon，索康)FOCH2OC—CH3OC3717a丁酸酯氢化考的松(Hydrocortisone17-butyrate)OCH2OHOCO-C(CH2)2CH3HOO17a丁酸酯氢化考的松(Hydrocortisone1738地奈德(desonide)OOHOOHOCH3HHHOCH3CH3CH3地奈德(desonide)OOHOOHOCH3HHHOCH339糠酸莫米松(Mometasonefruoate)CLOHOCH2CLOCCH3OCO糠酸莫米松(Mometasonefruoate)CLOHO40OHOCH2OHOCOH16916cortisolOHOCH2OHOCOH16916cortisol41FOHOOCOFluticasonePropionateFSFH2CCOC2H1CH3FOHOOCOFluticasonePropionateF42FOHOOCOInactivecarboxylicacidderivateFCOC2H3CH3HOFOHOOCOInactivecarboxylicaci43泼尼松龙泼尼松龙44身体部分治疗区域一次所需药物的指尖单位量（无性别差异）头和颈躯干（前）躯干（后）手臂手脚腿4.577316