主动脉疾病-英文课件

主动脉疾病-英文主动脉疾病-英文1DiseasesoftheaortaFredWU,MDApril19,2006Diseasesoftheaorta2CategoriesofaorticdiseaseAneurysmaPseudoaneurysmDissectionaPenetratingatheroscleroticulceraIntramuralhematomaAtheroscleroticdiseaseCoarctationCategoriesofaorticdisease3主动脉疾病-英文课件4ThoracicaorticaneurysmsAortopathyduetoheritablediseases(20%ofaneurysms)MarfansyndromeEhlers-DanlossyndromeFamilialAnnuloaorticectasiaaTurnersyndromeNoonansyndromeOsteogenesisimperfectaBicuspidaorticvalveCoarctationoftheaortaMetabolicdisorders(eg,homocystinuria,familialhypercholesterolemiaAorticarteritis(Takayasu's,giant-cell)TraumaPrenanSyphilis/infectiousCrackcocaineuseIatrogeniccauses(eg,cardiaccatheterization)AtherosclerosisHypertensionThoracicaorticaneurysms5MarfanSyndromeAutosomaldominantinheritanceMissensemutationinthefibrillingeneonchromosome15aPrevalenceis1in10,000(25%sporadaLeadingcauseofprematuredeathisaorticrootaneurysmleadingtodissection(cysticmedialdegeneration)MarfanSyndrome6MarfanSyndromeaGhentCriteriaIndexcaseaMajorcriteriain2differentorgansystemsandinvolvementinathirdorgansystemaFamilyhistoryaMajorcriterioninfamily/geneticsand1majorcriterioninanorgansystemandinvolvementinasecondorgansystemMarfanSyndrome7MarfanSyndromeSkeletalMajor(atleast4itemsMinoronlyPectuscannatumSpontaneouspneumothoraxLumbosacralduralectDecreasedelbowextensionCardiovascularProtrusioacetabularMinorDilatationoftheascendingaortavalsalvaDissectionoftheascendingaoMinorgharchedpalatewithcrowdingofMitralvalveprolapsewithorwithoutMFacialappearanceMitralannularcalcificationbeforeageOcularMajorDilationofthePAwithoutcausebeforeEctopialentisAbnormallyflatcornejoronlystdegreerelativewhoHypoplasticirisorciliarymuscleSkinandintegumentmutationinFBNlknowntoMinoronlyStriaenotassoclatedwithweightchange,pregnancyorstressMFSinfamilyRecurrentorincisionalherniasMarfanSyndrome8MarfanSyndromeSkeletalPulmonaryaMajor(atleast4items)MinoroWristandthumbCardiovascularnPesplanusacetabularDilatationoftheascendingaortaMinorvalsalvacum(moderate)DissectionoftheascendingMinorHigharchedpaMitralvalveprolapsewithorwithoutMaFacalMitralannularcalcificationbeforeageOcularofthePAwithoutcausebeforeMinorAbnormallyflatcorneaSkinandaMinoronlyStiaenotasMarfanSyndrome9FamilialTAASyndromesaAtleast19%ofpatientswiththoracicaorticaneurysms(withoutovertconnectivetissuedisorders)haveafamilyhistoryaTendtopresentyoungerthanthosepresentingsporadicallyaGeneticallyheterogeneousFamilialTAASyndromes10BicuspidaorticvalveaInitially,ascendingthoracicaorticaneurysmsinBAVthoughttobeduetopoststenoticdilatationa75%withcysticmedialnecrosisonpathologycomparedwith14%ofthosewithtricuspidaorticvalvesBicuspidaorticvalve11主动脉疾病-英文课件12主动脉疾病-英文课件13主动脉疾病-英文课件14主动脉疾病-英文课件15主动脉疾病-英文课件16主动脉疾病-英文课件17主动脉疾病-英文课件18主动脉疾病-英文课件19主动脉疾病-英文课件20主动脉疾病-英文课件21主动脉疾病-英文课件22主动脉疾病-英文课件23主动脉疾病-英文课件24主动脉疾病-英文课件25主动脉疾病-英文课件26主动脉疾病-英文课件27主动脉疾病-英文课件28主动脉疾病-英文课件29主动脉疾病-英文课件30主动脉疾病-英文课件31主动脉疾病-英文课件32主动脉疾病-英文课件33主动脉疾病-英文课件34主动脉疾病-英文课件35主动脉疾病-英文课件36主动脉疾病-英文课件37主动脉疾病-英文课件38主动脉疾病-英文课件39主动脉疾病-英文课件40主动脉疾病-英文课件41主动脉疾病-英文课件42主动脉疾病-英文课件43主动脉疾病-英文课件44主动脉疾病-英文课件45主动脉疾病-英文课件46主动脉疾病-英文课件47主动脉疾病-英文课件48主动脉疾病-英文课件49主动脉疾病-英文课件50主动脉疾病-英文课件51主动脉疾病-英文课件52主动脉疾病-英文课件53主动脉疾病-英文课件54主动脉疾病-英文课件55主动脉疾病-英文课件56主动脉疾病-英文课件57主动脉疾病-英文课件58主动脉疾病-英文课件59主动脉疾病-英文课件60主动脉疾病-英文课件61主动脉疾病-英文课件62主动脉疾病-英文课件63主动脉疾病-英文课件64主动脉疾病-英文课件65主动脉疾病-英文课件66主动脉疾病-英文课件67主动脉疾病-英文课件68主动脉疾病-英文课件69主动脉疾病-英文课件70主动脉疾病-英文课件71主动脉疾病-英文课件72主动脉疾病-英文课件73主动脉疾病-英文课件74谢谢你的阅读知识就是财富丰富你的人生71、既然我已经踏上这条道路，那么，任何东西都不应妨碍我沿着这条路走下去。——康德

72、家庭成为快乐的种子在外也不致成为障碍物但在旅行之际却是夜间的伴侣。——西塞罗

73、坚持意志伟大的事业需要始终不渝的精神。——伏尔泰

74、路漫漫其修道远，吾将上下而求索。——屈原

75、内外相应，言行相称。——韩非谢谢你的阅读知识就是财富71、既然我已经踏上这条道路，那么，75主动脉疾病-英文主动脉疾病-英文76DiseasesoftheaortaFredWU,MDApril19,2006Diseasesoftheaorta77CategoriesofaorticdiseaseAneurysmaPseudoaneurysmDissectionaPenetratingatheroscleroticulceraIntramuralhematomaAtheroscleroticdiseaseCoarctationCategoriesofaorticdisease78主动脉疾病-英文课件79ThoracicaorticaneurysmsAortopathyduetoheritablediseases(20%ofaneurysms)MarfansyndromeEhlers-DanlossyndromeFamilialAnnuloaorticectasiaaTurnersyndromeNoonansyndromeOsteogenesisimperfectaBicuspidaorticvalveCoarctationoftheaortaMetabolicdisorders(eg,homocystinuria,familialhypercholesterolemiaAorticarteritis(Takayasu's,giant-cell)TraumaPrenanSyphilis/infectiousCrackcocaineuseIatrogeniccauses(eg,cardiaccatheterization)AtherosclerosisHypertensionThoracicaorticaneurysms80MarfanSyndromeAutosomaldominantinheritanceMissensemutationinthefibrillingeneonchromosome15aPrevalenceis1in10,000(25%sporadaLeadingcauseofprematuredeathisaorticrootaneurysmleadingtodissection(cysticmedialdegeneration)MarfanSyndrome81MarfanSyndromeaGhentCriteriaIndexcaseaMajorcriteriain2differentorgansystemsandinvolvementinathirdorgansystemaFamilyhistoryaMajorcriterioninfamily/geneticsand1majorcriterioninanorgansystemandinvolvementinasecondorgansystemMarfanSyndrome82MarfanSyndromeSkeletalMajor(atleast4itemsMinoronlyPectuscannatumSpontaneouspneumothoraxLumbosacralduralectDecreasedelbowextensionCardiovascularProtrusioacetabularMinorDilatationoftheascendingaortavalsalvaDissectionoftheascendingaoMinorgharchedpalatewithcrowdingofMitralvalveprolapsewithorwithoutMFacialappearanceMitralannularcalcificationbeforeageOcularMajorDilationofthePAwithoutcausebeforeEctopialentisAbnormallyflatcornejoronlystdegreerelativewhoHypoplasticirisorciliarymuscleSkinandintegumentmutationinFBNlknowntoMinoronlyStriaenotassoclatedwithweightchange,pregnancyorstressMFSinfamilyRecurrentorincisionalherniasMarfanSyndrome83MarfanSyndromeSkeletalPulmonaryaMajor(atleast4items)MinoroWristandthumbCardiovascularnPesplanusacetabularDilatationoftheascendingaortaMinorvalsalvacum(moderate)DissectionoftheascendingMinorHigharchedpaMitralvalveprolapsewithorwithoutMaFacalMitralannularcalcificationbeforeageOcularofthePAwithoutcausebeforeMinorAbnormallyflatcorneaSkinandaMinoronlyStiaenotasMarfanSyndrome84FamilialTAASyndromesaAtleast19%ofpatientswiththoracicaorticaneurysms(withoutovertconnectivetissuedisorders)haveafamilyhistoryaTendtopresentyoungerthanthosepresentingsporadicallyaGeneticallyheterogeneousFamilialTAASyndromes85BicuspidaorticvalveaInitially,ascendingthoracicaorticaneurysmsinBAVthoughttobeduetopoststenoticdilatationa75%withcysticmedialnecrosisonpathologycomparedwith14%ofthosewithtricuspidaorticvalvesBicuspidaorticvalve86主动脉疾病-英文课件87主动脉疾病-英文课件88主动脉疾病-英文课件89主动脉疾病-英文课件90主动脉疾病-英文课件91主动脉疾病-英文课件92主动脉疾病-英文课件93主动脉疾病-英文课件94主动脉疾病-英文课件95主动脉疾病-英文课件96主动脉疾病-英文课件97主动脉疾病-英文课件98主动脉疾病-英文课件99主动脉疾病-英文课件100主动脉疾病-英文课件101主动脉疾病-英文课件102主动脉疾病-英文课件103主动脉疾病-英文课件104主动脉疾病-英文课件105主动脉疾病-英文课件106主动脉疾病-英文课件107主动脉疾病-英文课件108主动脉疾病-英文