Thimerosal-Sodium-ethylmercurithiosalicylate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEThimerosalCat.No.:HY-19588CASNo.:54-64-8Synonyms:Sodiumethylmercurithiosalicylate分⼦式:C₁₁H₁₅HgNaO₂S分⼦量:434.88作⽤靶点:Antibiotic作⽤通路:Anti-infection储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验H2O:100mg/mL(229.95mM;Needultrasonicandwarming)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.2995mL11.4974mL22.9948mL5mM0.4599mL2.2995mL4.5990mL10mM0.2299mL1.1497mL2.2995mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Thimerosal⼀种含汞疫防腐剂，也神经发育障碍病因中的⼀个可疑因素。体内研究TheThimerosal(THIM)administrationincreasesμ-opioidreceptors(MORs)densityintheperiaqueductalgray(PAG)inadose-dependentmanner.TreatmentwithhigherdosesofThimerosalstatisticallysignificantlyincreasesMORdensityinthedorsomedialperiaqueductalgray(DMPAG)andlateralperiaqueductalgray1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE(LPAG)regions.Atthedose3,000μgHg/kg,ThimerosalalsoaugmentsMORdensityinthecaudateputamen(CPU).Incontrast,theadministrationofThimerosalatbothhigherdosesdecreasesMORdensityinthedentategyrus(DG)[1].Thimerosaladministration(4injections,i.m.,240μgHg/kgonpostnataldays7,9,11,15)induceslastingchangesinaminoacidoverflow:anincreaseofglutamateandaspartateaccompaniedbyadecreaseofglycineandalanine;measured10to14weeksaftertheinjections.FourinjectionsofThimerosalatadoseof12.5μgHg/kgdonotalterglutamateandaspartateconcentrationsatmicrodialysistime.ApplicationofThimerosaltotheprefrontalcortex(PFC)inperfusionfluidevokesarapidincreaseofglutamateoverflow.Coadministrationoftheneurosteroid,dehydroepiandrosteronesulfate(DHEAS;80mg/kg;i.p.)preventstheThimerosaleffectonglutamateandaspartate;thesteroidalonehasnoinfluenceontheseaminoacids.Coapplicationofdehydroepiandrosteronesulfate(DHEAS)withThimerosalinperfusionfluidalsoblockstheacuteactionofThimerosalonglutamate[2].PROTOCOLAnimalMaleratsareusedinthisstudy.Onthe20thpostnatalweek,theanimalsareeuthanizedbypentobarbitalAdministration[1]overdosing,andthendecapitated.TheratstreatedwithtwohigherdosesofThimerosal(THIM)(1,440and3,000μgHg/kg)arefromtheoriginallitters,whichareusedfordifferentbehavioralandpathologicaltests,butareexperimentallynaïve.Aseparategroupofexperimentallynaïverats,treatedwithtwolowerdosesofThimerosal,12and240μgHg/kg(4litterspereachdrug-treatment)issacrificedonthe8thpostnatalweekaccordingtothesameprocedure.Eachexperimentalgroupiscomposedof5animals,with2atthemostcomingfromthesamelitter[1].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.REFERENCES[1].OlczakM,etal.Neonataladministrationofthimerosalcausespersistentchangesinmuopioidreceptorsintheratbrain.NeurochemRes.2010Nov;35(11):1840-7.[2].Duszczyk-BudhathokiM,etal.Administrationofthimerosaltoinfantratsincreasesoverflowofglutamateandaspartateintheprefrontalcortex:protectiveroleofdehydroepiandrosteronesulfate.NeurochemRes.2012Feb;37(2):436-47.McePdfHeightCaution:Producthasno