肿瘤抗血管生成疗法课件

第九章肿瘤抗血管生成疗法Angiogenesis第九章肿瘤抗血管生成疗法1詞彙介紹血管生成(Angiogenesis)Angeion:sselgenesis:formation·癌細胞轉移(Metastasis內皮細胞(endothelialcel促血管生成以及抑制血管生成之因子(Anti-andpro-angiogenicfactor詞彙介紹2NormalangiogenesisNormalAngiogenesisinChildrenNormalAngiogenesisinAdultsNormalangiogenesis3正常胚胎血管新生(NormalangiogenesisinEmbryo〉胚胎發育過程中,需要大量的養分以及代謝,新生之血管生成才足以供應快速發育之胚胎正常之生長所需正常胚胎血管新生4正常成體血管新生NormalangiogenesisinAdults)≯因為新生之組織需要大量的營養成分以及修補物質’而免疫糸統的成員亦在此過程中扮演重要角色’而為新生之血管所運送至受傷的組織內。正常成體血管新生5Historyofantiangiogenicdrugs1971:Thefieldbeganinearly1970swithJudahFolkman'shypothesisthattumorgrowthwouldbehaltedifitweredeprivedofabloodsupply1989:Dr.NapoleneFerraidentifiedandisolateVEGF1996:Dr.JefferyIsnerpublishedfirstclinicaltrialsregardingVEGF2004:FDAapprovesfirstantiangiogenicdrugtotreatcolorectalcancer(AvastinHistoryofantiangiogenicdrug6ArticleTalkWIKIPEDIAJudahFolkmanWildpedia,thefreeencyclopediastbestknownforhisresearchbywhichatumorattractsbloodvesselstonourishitselfandsustainitsaxistence.HefoundedthefieldofangiogenesisresearchwhichumberoftherapiesbasedoninhibitingorstimulatingneoascularizationRandomartdenEarly2WarkenangiogenesisAboutwkpedlaReferencessExtemallinksRacanchangEsContactWikipediaEarlylifecouldoffercuresinadditiontocomfort.Hisfatherreplied,Inthatcase,youcanbearabbi-likedoctor."wordshissontooktoheatily''spaniedhisfather,arabbi,onvisitstohospitalpatientsTLanguagesFolkmangraduatedfromTheOhioStateUniversityin1953,andthenHarvardMedicalSchoolain1957.WhilestillastudentatHarvardMaduation.hedidhissurgicalresidencyatMassachusettsGeneralHospital,whereherosetotherankofChiefResidentinSurgery.DuDeutschetween1960and1962.FolkmanservedintheUnitedStatesNawasalieutenant.wherehestudiedbloodvesselgrowthattheNationalEspanolany,Folkmaninventedanimplantabledevicefortimeddrugrelease4anddonateditpatent-freetotheWarldPopulationCouncil.ItcorK。nLetzebuergeschIn1971.hereportedintheNewEnglandJoumalofMedicmethatallI0r5areangiogenesis-dependent.ifatumorcouldbestopporsk(bokmal>haughhishypothesiswasinitiallydisregardedbymostexpertsinthefieldpersistedwithhisresearchPortuguesAftermorethanadecade.histheorybecamewidelyacceptedandisnowbeingexploitedinthetreatmentofagrowingnumberofdiseaseArticleTalk7obusttumorgrowthrequiresthepresenceofalocalvascularnetworlthatsuppliesbothoxygenandnutrientstotumorcellsAngiogenesisanti-angiogenic6k2)actorsTheAngiogenicBalanceobusttumorgrowthrequiresth8contents血管生成与肿瘤(1)血管生成的一般过程(2)肿瘤血管生成(3)肿瘤血管生成与肿瘤的发生、生长和转移·二、肿瘤血管生成的评估三、血管生成抑制剂研究及临床应用现状·四、抗血管生成治疗与提高放射治疗敏感性·五、抗血管生成药物临床试验存在的一些问题contents9第一节、血管生成与肿瘤(1)血管生成的一般过程血管生成anglogenesIs)是指在机体生长发育过程中或创伤修复、缺血缺氧和炎症等情况下,Angiogenesis原有微血管内皮细胞(endothelialcell,EC)经过生芽、迁移、增殖与基质重塑等形成新毛细血管的过程。第一节、血管生成与肿瘤10肿瘤抗血管生成疗法课件11肿瘤抗血管生成疗法课件12肿瘤抗血管生成疗法课件13肿瘤抗血管生成疗法课件14肿瘤抗血管生成疗法课件15肿瘤抗血管生成疗法课件16肿瘤抗血管生成疗法课件17肿瘤抗血管生成疗法课件18肿瘤抗血管生成疗法课件19肿瘤抗血管生成疗法课件20肿瘤抗血管生成疗法课件21肿瘤抗血管生成疗法课件22肿瘤抗血管生成疗法课件23肿瘤抗血管生成疗法课件24肿瘤抗血管生成疗法课件25肿瘤抗血管生成疗法课件26肿瘤抗血管生成疗法课件27肿瘤抗血管生成疗法课件28肿瘤抗血管生成疗法课件29肿瘤抗血管生成疗法课件30肿瘤抗血管生成疗法课件31肿瘤抗血管生成疗法课件32肿瘤抗血管生成疗法课件33肿瘤抗血管生成疗法课件34肿瘤抗血管生成疗法课件35肿瘤抗血管生成疗法课件36肿瘤抗血管生成疗法课件37肿瘤抗血管生成疗法课件38肿瘤抗血管生成疗法课件39肿瘤抗血管生成疗法课件40肿瘤抗血管生成疗法课件41肿瘤抗血管生成疗法课件42肿瘤抗血管生成疗法课件43肿瘤抗血管生成疗法课件44肿瘤抗血管生成疗法课件45肿瘤抗血管生成疗法课件46肿瘤抗血管生成疗法课件47肿瘤抗血管生成疗法课件48肿瘤抗血管生成疗法课件49肿瘤抗血管生成疗法课件50肿瘤抗血管生成疗法课件51肿瘤抗血管生成疗法课件52肿瘤抗血管生成疗法课件53肿瘤抗血管生成疗法课件54肿瘤抗血管生成疗法课件55肿瘤抗血管生成疗法课件56肿瘤抗血管生成疗法课件57肿瘤抗血管生成疗法课件58肿瘤抗血管生成疗法课件59肿瘤抗血管生成疗法课件60肿瘤抗血管生成疗法课件61肿瘤抗血管生成疗法课件62肿瘤抗血管生成疗法课件63肿瘤抗血管生成疗法课件64肿瘤抗血管生成疗法课件65肿瘤抗血管生成疗法课件66肿瘤抗血管生成疗法课件67肿瘤抗血管生成疗法课件68肿瘤抗血管生成疗法课件69肿瘤抗血管生成疗法课件70肿瘤抗血管生成疗法课件71肿瘤抗血管生成疗法课件72肿瘤抗血管生成疗法课件73肿瘤抗血管生成疗法课件74肿瘤抗血管生成疗法课件75肿瘤抗血管生成疗法课件76肿瘤抗血管生成疗法课件77肿瘤抗血管生成疗法课件78肿瘤抗血管生成疗法课件79肿瘤抗血管生成疗法课件80肿瘤抗血管生成疗法课件81肿瘤抗血管生成疗法课件82第九章肿瘤抗血管生成疗法Angiogenesis第九章肿瘤抗血管生成疗法83詞彙介紹血管生成(Angiogenesis)Angeion:sselgenesis:formation·癌細胞轉移(Metastasis內皮細胞(endothelialcel促血管生成以及抑制血管生成之因子(Anti-andpro-angiogenicfactor詞彙介紹84NormalangiogenesisNormalAngiogenesisinChildrenNormalAngiogenesisinAdultsNormalangiogenesis85正常胚胎血管新生(NormalangiogenesisinEmbryo〉胚胎發育過程中,需要大量的養分以及代謝,新生之血管生成才足以供應快速發育之胚胎正常之生長所需正常胚胎血管新生86正常成體血管新生NormalangiogenesisinAdults)≯因為新生之組織需要大量的營養成分以及修補物質’而免疫糸統的成員亦在此過程中扮演重要角色’而為新生之血管所運送至受傷的組織內。正常成體血管新生87Historyofantiangiogenicdrugs1971:Thefieldbeganinearly1970swithJudahFolkman'shypothesisthattumorgrowthwouldbehaltedifitweredeprivedofabloodsupply1989:Dr.NapoleneFerraidentifiedandisolateVEGF1996:Dr.JefferyIsnerpublishedfirstclinicaltrialsregardingVEGF2004:FDAapprovesfirstantiangiogenicdrugtotreatcolorectalcancer(AvastinHistoryofantiangiogenicdrug88ArticleTalkWIKIPEDIAJudahFolkmanWildpedia,thefreeencyclopediastbestknownforhisresearchbywhichatumorattractsbloodvesselstonourishitselfandsustainitsaxistence.HefoundedthefieldofangiogenesisresearchwhichumberoftherapiesbasedoninhibitingorstimulatingneoascularizationRandomartdenEarly2WarkenangiogenesisAboutwkpedlaReferencessExtemallinksRacanchangEsContactWikipediaEarlylifecouldoffercuresinadditiontocomfort.Hisfatherreplied,Inthatcase,youcanbearabbi-likedoctor."wordshissontooktoheatily''spaniedhisfather,arabbi,onvisitstohospitalpatientsTLanguagesFolkmangraduatedfromTheOhioStateUniversityin1953,andthenHarvardMedicalSchoolain1957.WhilestillastudentatHarvardMaduation.hedidhissurgicalresidencyatMassachusettsGeneralHospital,whereherosetotherankofChiefResidentinSurgery.DuDeutschetween1960and1962.FolkmanservedintheUnitedStatesNawasalieutenant.wherehestudiedbloodvesselgrowthattheNationalEspanolany,Folkmaninventedanimplantabledevicefortimeddrugrelease4anddonateditpatent-freetotheWarldPopulationCouncil.ItcorK。nLetzebuergeschIn1971.hereportedintheNewEnglandJoumalofMedicmethatallI0r5areangiogenesis-dependent.ifatumorcouldbestopporsk(bokmal>haughhishypothesiswasinitiallydisregardedbymostexpertsinthefieldpersistedwithhisresearchPortuguesAftermorethanadecade.histheorybecamewidelyacceptedandisnowbeingexploitedinthetreatmentofagrowingnumberofdiseaseArticleTalk89obusttumorgrowthrequiresthepresenceofalocalvascularnetworlthatsuppliesbothoxygenandnutrientstotumorcellsAngiogenesisanti-angiogenic6k2)actorsTheAngiogenicBalanceobusttumorgrowthrequiresth90contents血管生成与肿瘤(1)血管生成的一般过程(2)肿瘤血管生成(3)肿瘤血管生成与肿瘤的发生、生长和转移·二、肿瘤血管生成的评估三、血管生成抑制剂研究及临床应用现状·四、抗血管生成治疗与提高放射治疗敏感性·五、抗血管生成药物临床试验存在的一些问题contents91第一节、血管生成与肿瘤(1)血管生成的一般过程血管生成anglogenesIs)是指在机体生长发育过程中或创伤修复、缺血缺氧和炎症等情况下,Angiogenesis原有微血管内皮细胞(endothelialcell,EC)经过生芽、迁移、增殖与基质重塑等形成新毛细血管的过程。第一节、血管生成与肿瘤92肿瘤抗血管生成疗法课件93肿瘤抗血管生成疗法课件94肿瘤抗血管生成疗法课件95肿瘤抗血管生成疗法课件96肿瘤抗血管生成疗法课件97肿瘤抗血管生成疗法课件98肿瘤抗血管生成疗法课件99肿瘤抗血管生成疗法课件100肿瘤抗血管生成疗法课件101肿瘤抗血管生成疗法课件102肿瘤抗血管生成疗法课件103肿瘤抗血管生成疗法课件104肿瘤抗血管生成疗法课件105肿瘤抗血管生成疗法课件106肿瘤抗血管生成疗法课件107肿瘤抗血管生成疗法课件108肿瘤抗血管生成疗法课件109肿瘤抗血管生成疗法课件110肿瘤抗血管生成疗法课件111肿瘤抗血管