辅酶一(NAD)与老年化疾病课件

Age-relateddiseasesandcancer

Age-relateddiseasesCOENZYMEI精品1Age-relateddiseasesandcanceCONTENTSA.NADbiosyntheticpathwaysandmetabolismB.NADconsumingenzymesinhealthanddiseaseC.Age-relateddiseasesandcancerD.MechanismsofNADPrecursorsinhumansandanimalmodelsE.NADandthehallmarksofaging精品2CONTENTSA.NADbiosyntheticpaA.NADbiosyntheticpathwaysandmetabolism精品3A.NADbiosyntheticpathwaysanNADbiosyntheticpathwaysandmetabolismEricVerdin.(2015).SpecialSection350（6265）:1208-1213.NAD

biosyntheticpathwaysandmetabolismindifferentcellularcompartments.精品4NADbiosyntheticpathwaysandB.NADconsumingenzymesinhealthanddisease精品5B.NADconsumingenzymesinheaNADconsumingenzymesinhealthanddiseaseEF.Fang,.(2017).NAD+:akeymetabolicregulatorwithgreattherapeuticpotential:1120-1143.NADavailabilitycaninfluencetheactivityofthreegroupsofmasterregulatorenzymesthesirtuins,thePARPsandcyclicADP-ribosesynthases.EachgroupofenzymesregulatemanybiologicalprocessesandcanthuscouplechangesinNADlevelswithawiderangeofphysiologicalresponses.精品6NADconsumingenzymesinhealtC.Age-relateddiseasesandcancer精品7C.Age-relateddiseasesandcan1980s1930s……Age-relateddiseasesandcancercouldbetheconsequenceofadeclineinNAD+concentrationsAmandaGarrido(2017).Trendincancer181:181-199.Age-relateddiseasesandcancerMetabolicsyndromeincludingcardiovasculardisorders,type2diabetesandobesity,Neurodegenerativediseases

suchasAlzheimerandParkinsondiseases,arthritis,andosteoporosis,andcancer

aresomeofthediseasesthatcommonlyaffecthumanhealthduringaging.精品81980s1930s……Age-relateddiseasD.BenefitsandmechanismsofNADprecursorsinhumansandanimalmodels精品9D.BenefitsandmechanismsofNBenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品10BenefitsandmechanismsofNADBenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品11BenefitsandmechanismsofNADBenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品12BenefitsandmechanismsofNADE.NADandthehallmarksofaging精品13E.NADandthehallmarksofagiNADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品14NADandthehallmarksofagingNADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品15NADandthehallmarksofagingNADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品16NADandthehallmarksofagingNADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品17NADandthehallmarksofagingTheEnd精品18TheEnd精品18Age-relateddiseasesandcancer

Age-relateddiseasesCOENZYMEI精品19Age-relateddiseasesandcanceCONTENTSA.NADbiosyntheticpathwaysandmetabolismB.NADconsumingenzymesinhealthanddiseaseC.Age-relateddiseasesandcancerD.MechanismsofNADPrecursorsinhumansandanimalmodelsE.NADandthehallmarksofaging精品20CONTENTSA.NADbiosyntheticpaA.NADbiosyntheticpathwaysandmetabolism精品21A.NADbiosyntheticpathwaysanNADbiosyntheticpathwaysandmetabolismEricVerdin.(2015).SpecialSection350（6265）:1208-1213.NAD

biosyntheticpathwaysandmetabolismindifferentcellularcompartments.精品22NADbiosyntheticpathwaysandB.NADconsumingenzymesinhealthanddisease精品23B.NADconsumingenzymesinheaNADconsumingenzymesinhealthanddiseaseEF.Fang,.(2017).NAD+:akeymetabolicregulatorwithgreattherapeuticpotential:1120-1143.NADavailabilitycaninfluencetheactivityofthreegroupsofmasterregulatorenzymesthesirtuins,thePARPsandcyclicADP-ribosesynthases.EachgroupofenzymesregulatemanybiologicalprocessesandcanthuscouplechangesinNADlevelswithawiderangeofphysiologicalresponses.精品24NADconsumingenzymesinhealtC.Age-relateddiseasesandcancer精品25C.Age-relateddiseasesandcan1980s1930s……Age-relateddiseasesandcancercouldbetheconsequenceofadeclineinNAD+concentrationsAmandaGarrido(2017).Trendincancer181:181-199.Age-relateddiseasesandcancerMetabolicsyndromeincludingcardiovasculardisorders,type2diabetesandobesity,Neurodegenerativediseases

suchasAlzheimerandParkinsondiseases,arthritis,andosteoporosis,andcancer

aresomeofthediseasesthatcommonlyaffecthumanhealthduringaging.精品261980s1930s……Age-relateddiseasD.BenefitsandmechanismsofNADprecursorsinhumansandanimalmodels精品27D.BenefitsandmechanismsofNBenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品28BenefitsandmechanismsofNADBenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品29BenefitsandmechanismsofNADBenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918精品30BenefitsandmechanismsofNADE.NADandthehallmar