v-pcsstfsbl00缓冲液存储生物工程园300单元PCS系统储存罐区功能说明

Bufferstorage FunctionalSpecificationofPCSofBioengineeringParkUnit3100生物工程园3100单元PCS系统缓冲液罐区功能说RevisionHistory修订历版修订内Revised修订日The Scope范 Relateds关联文 ReferenceGuideline参考指 Listof s参考文件.....................................................................................SYSTEMCONTROLFUNCTION系统控制功 CIPROUTECIP路径定 STATUSEDEFINE状态定 CIPstationCOMM CIP站通讯状态定 Bufferstorage缓冲液 EM01:BS_...................................................................................................................................GeneralDescription通用描 P&IDiagram功能 CMTable控制模块 ParametersTable参数 FlowChart流程 EM02:BS_ GeneralDescription通用描 P&IDiagram功能 CMTable控制模块 ParametersTable参数 FlowChart流程 EM03: GeneralDescription通用描 P&IDiagram功能 CMTable控制模块 ParametersTable参数 FlowChart流程 EM04: GeneralDescription通用描 P&IDiagram功能 CMTable控制模块 ParametersTable参数 FlowChart流程 EM05:BS_TP_TRANS(forT311002012&T311002009 EM06:BS_TP_TRANS(forT311002012&T311002009trans EM07:BS_UYS_TRANS(forT311002012–UYS311001001trans EM08:BS_UF/DF_TRANS(forT311002016&T311002022to EM09: EM10: Reviewand审核与批Draftedby起草部职日Austar-调试工程年月Reviewedby审核部职日Austar-验证工程年月工程工程部工程年月生产车间生产线年月设备设备自控工程年月QA工程年月QA验证工程年月Approvedby批准部职日QA质量副总年月Scope范ThisdefinesthecontrolstrategytomeetbufferstoragecontrolrequirementofPCSofQILUBio-engineeringParkUnit3100.本文件定义的控制策略用于满足齐鲁生物工程园3100单元PCS系统缓冲液罐区工段控制需Relateds关联文ReferenceGuideline参考指ThisFunctionalSpecificationhasbeenwrittentomeettheguidanceonFunctionSpecificationofcomputerizedsystemcontainedinGAMPGPGARisk-BasedApproachtoGXPProcessControlGAMP良好实践指南-GxPGMP计ListofReferences参考文ThefollowingsarereferencedinthisNo.文s文档名UserRequirementV-PCS-QualityandProjectFunctionalSYSTEMCONTROLFUNCTION系统控制功CIPROUTECIP路径定Accordingtodifferentcleaning,thevalvesofCIPwatersupplyandreturnlooparedefinedas针对不同的目标，将所用到的公共CIP供水及回流管的阀门进行路径定义序阀门Route路_____123456789序阀门Route路_____序阀门Route路_____序阀门Route路_____123456789CIP311001002-序阀门Route路_____CIP311001002-序阀门Route路_____CIPS2序阀门Route路_____123456789CIP311001002-序阀门Route路_____CIPS2序阀门Route路_装柱123456789CIP311001002-序阀门Route路_装柱CIP311001002-序阀门Route路_装柱注释：每列代表一个目标，绿色标识阀门（最左侧阀门列表）为需打开阀门，无色为需关闭阀序阀门Route路123456789CIP311001002-序阀门Route路CIP311001002-序阀门Route路序阀门Route路123456789CIP311001002-序阀门Route路CIP311001002-序阀门Route路注释：每列代表一个目标，绿色标识阀门（最左侧阀门列表）为需打开阀门，无色为需关闭阀序阀门Route路123456789CIP311001002-序阀门Route路CIP311001002-序阀门Route路注释：每列代表一个目标，绿色标识阀门（最左侧阀门列表）为需打开阀门，无色为需关闭阀序阀门Route路123456789CIP311001002-序阀门Route路CIP311001002-序阀门Route路注释：每列代表一个目标，绿色标识阀门（最左侧阀门列表）为需打开阀门，无色为需关闭阀STATUSEDEFINE状态定Accordingtodifferent,statusesaredefinedas序配料罐状数值定储料罐状数值定转料系统状定）1检修、1检修、1完整性测试合12待清2待清2待清23已清3已清3已清34检漏合4检漏合4检漏合45已灭5已灭5已灭56运行6运行6运行6CIPstationCOMM CIP站通讯状态定AccordingtoCIPstation,COMMaredefinedasPCS→序名数值类注1请求命令；0无，1请求2启动命令；0无，1开始3暂停命令；0无，1泵和压空停止，计时器停4中断命令；0无，1CIP立即停止5介质输送允许；0无，1泵和压空使能6PCS存在，CIP无响应动作7回流泵允许；0无，1回流泵使能8当前罐液位，管道时此值为9模式；0无1234每秒加1CIP站检测到此值5秒不变时，认为通讯断4共计80个标记位，每位代表一个点终淋电导测试使能；0不能，1允许CIP站计时使能；0不能1允许CIP→序名数值类注1CIP站是否能够使用(可用状态：无重要、处于控制状态、没有运行)；0无，1可用2CIP站运行状态；0待机，1运行3CIP站暂停状态；0无，1暂4CIP站输送状态；0无，1正在输送液压空5CIP站结束状态0无，1结束；（此信仅维持6CIP站状态；0无，1存在需操作检查7CIP站反馈结果；1电导不合格失败电导合格成功8当前动作无纯化水预冲洗吹扫纯化水冲吹碱液冲吹酸液冲吹注射水终吹碱液液位调碱液配碱液罐自酸液罐自系统排每秒加1PCS检测到此值5秒不变化时认为通讯断Bufferstorage缓冲液Buffer缓冲罐SFC11.罐体2.罐体灭3.Keep罐体充4.罐体排5.罐体吹紧急停止状态处暂停状态处暂停恢复处21.AddWFI人工定量加注射2AddWFI液位维持加注射3.罐体4.罐体灭5.Keep罐体充6.罐体排7.罐体吹紧急停止状态处暂停状态处暂停恢复处31.停止(中断2.启3.Defined定时运41.至层析转接板转2.Trans至层析转接板管路3.Trans至层析转接板管路灭紧急停止状态处暂停状态处暂停恢复处5T311002012&T3110020091.至层析转接板和超滤转紧急停止状态处暂停状态处暂停恢复处6T311002012&T311002009trans1.Trans至层析转接板管路2.Trans至层析转接板管路灭紧急停止状态处暂停状态处暂停恢复处7trans1.Trans至超滤管路2.Trans至超滤管路灭紧急停止状态处暂停状态处暂停恢复处8(forT311002016&T311002022to1.至超滤转2.Trans至超滤管路3.Trans至超滤管路灭Buffer缓冲罐SFC紧急停止状态处暂停状态处暂停恢复处91.至产品储罐转2.Trans至产品储罐管路3.Trans至产品储罐管路灭紧急停止状态处暂停状态处暂停恢复处1.至装柱间转2.Trans至装柱间管路紧急停止状态处暂停状态处暂停恢复处EM01:EQMEQMClass EQM1.2.3.Keep4.5.GeneralDescription通用描TheEQMclassisusedtocontroltheBuffer 该设备模块用于缓冲液罐的控制P&IDiagram功能CIP（examples:T311002020）IPCMTable控制模块DEVICEDescriptionRef2.1CIPPS罐顶阀前料罐顶罐顶管路分支罐底管路罐底出口前料罐底管路出口罐底出口后料罐底管路出口后罐底管路出口后DEVICEDescription点标记位定义块DEVICEDescriptionRef2.1CIPPS罐顶阀前料罐顶罐顶管路分支罐底管路罐底出口前料罐底管路出口罐底出口后料罐底管路出口后罐底管路出口后DEVICEDescription点标记位定义块DEVICEDescriptionRef2.1CIPPS罐顶阀前料罐顶罐顶管路分支罐底管路罐底出口前料罐底管路出口罐底出口后料罐底管路出口后罐底管路出口后DEVICEDescription点标记位定义块DEVICEDescriptionRef2.1CIPPS罐顶阀前料罐顶罐顶管路分支罐底管路罐底出口前料罐底管路出口罐底出口后料罐底管路出口后罐底管路出口后DEVICEDescription点标记位定义块ParametersTable参数CIP1CIP5CIP1012030121.52.2800.80.660点间30105300.20.050.0555505CIP浸泡液位上0.2CIP浸泡液位下0.05CIP浸泡次数（阶段156000000动作号（0剩余循环次数（于0FlowChart流程CIP罐体IntheCIPlogic,theCleaningfluidisprovidedbyCIPstation, toppass-throughvalveandsprayvalveaccordingtothesetti peneachpulsation,pulsationcycle.Aftereachstagetoincreaseafterimmersioncleaningspray,CIPstationinteractwiththeneedtore-setimmersioncleaning, bottomvalveisclosed,stoppedafterthesetlevelintotheCIPcleaningsolution,soakthesetmixingtime,tosoakstirringtimeopen bottomvalve,waterrinsestageissetforanimmersioncycles,afterthecycleiscompletestopCIP. foranadvancedsolutionforallopenagain在运行阶段，液由P提供。罐顶直通阀门和喷淋阀按设定脉动时间逐个打开，进行环脉动。每阶段喷后加浸泡与P站，需设浸泡液，闭罐底后达到设定液位后进P，设定泡拌时间达浸泡搅时后开罐阀水冲洗段设定浸泡P。_STAStep17CIPStep17CIPA1MessageSUCCESS,_STAtoA2resetP_REQUEST_ORDER,P_CIP_START_ORDER,PUMP_AIR_SUPPLY-ORDER,VALVES&CIPVG&CIPStation&STIRhavebeenCIP_P_9Step8TIMER1TIMER1TIMER2LCT01<L_L_STIR&CYCLESACTIONNUMBER<>Actualactionnumber&ActualactionnumberNOTStep19A1ReleaseFCV01~FCV21;releaseCIPPVGandCIPstationandStep18CIPA1resetP_REQUEST_ORDER,P_CIP_START_ORDER,PUMP_AIR_SUPPLY-ORDER,A2MessageoperatorA2closeFCV01~FCV21,setCIPVGtocloserouteUP_PUSLStep16CIPA1disableStep14A1setStep7A1openFCV11;resetTIMER1;StopSTIR01;resetSTIR_STA;resetP_CIP_PAUSE_ORDER;setP_CIP_RETURNPUMP_ORDER;SetP_CIP-EN_TIMER;CloseStep10A1resetA2resetStep6A1setTIMER_SP11tosetP_CIP_PAUSE_ORDER;StartSTIR01;setSTIR_STA;A2startStep9A1setSP16toTIMER2,openFCV18,FCV21;setDRAIN_CTRL;A2Step5MEDIUMA1CloseFCV11,resetP_CIP-setACTIONNUMBERtoResetStep13A1openFCV11;resetTIMER1;StopSTIR01;resetSTIR_STA;enableCYCLES_CACU;setP_CIP_RETURNPUMP_ORDER;A2disableStep12A1setTIMER_SP11toTIMER1;StartSTIR01;setresetP_CIP_PUMP_AIR_SUPPLY_ORDER;A2startTIMER1Step11MEDIUMA1CloseFCV11,resetsetP_CIP_PUMP_AIR_SUPPLY_ORDER;resetP_CIP_EN_TIMERsetACTIONNUMBERtoActualactionnumberStep4Step3CIPA1setP_REQUEST_ORDER,P_CIP_START_ORDER,P_CIP-PUMP_AIR_SUPPLY-ORDER,P_CIP-resetP_CIP_EN_Conductivity;enable UP_PUSLStep2VALVEA1closeFCV01,FCV02,FCV05,FCV07~FCV10,FCV12,FCV15,FCV17,FCV18,FCV20,FCV21;A2openFCV03,FCV04,FCV11,FCV13,FCV14,FCV16,FCV19;setCYCLEStoNUMBER_SP;sendCIP_TYPEtoP_CIP_PROG_TYPE,CIPVG_ROUTEtoP_CIP_SELECTED_ORDER_UNITStep1A1acquireandCIPVGandCIPStep15SYSTEMIPInIntheSIPlogic,theclean injectionintothevesseltoheating.Thevesseltemperature,theventfilterdraintemperature,thevesseldraintemperaturewillbemonitored,whenthesethreetemperatureatthesametimetoreachedsterilizationtemperatureforaperiodtime,thenthesterilizationissuccessful.Ifanytemperatureislowerthesterilizationtemperature,thenthesterilizationtimerisstop,untilthetemperatureisok,thesterilizationtimerisresetandrestart.3个温度同时达到灭菌温度且持续一段时间后，才认为灭菌成功。在灭菌过程中，如果任何一个温lyrespiratortopurgethewaterfilm,andthensterilizedbyheating;Sterilizationheatingstage, bottomvalveandexhaustvalveopensuntilitreachesthesettemperature;aftersterilizationtime,pure forthe valveinthe pressureorhigherthanthehighestreferencetemperature(threelowesttemperaturevalue)ishigherthanthetemperatureoffvalvecapclosed,thereferencetemperatureislessthanthelowerlimitofthetemperatureofthevalveopeningopen;Afterthesterilizationprocess,closethetrapdischargerespirator, bottomremainsopen;openthecompressedairvalve, bottomdischargeopeningonly10seconds;whenthebodytemperaturedropsopenjacketcoolanttemperaturepoint,indicatingoperativesjacketcoolingoperation;waitforthetemperaturetocooldownagainwhenthetemperatureof point,Buckexhausttodwelllimit,closedmouthaftercleaning bottomand bottomdrainvalvedischargerefrigerantprompttheoperatortoclosethejacket,end.Referringto pressureandtemperaturetakefullhighlimitalarm;SIPfailureneed10秒；当罐体温度降到开启夹套冷媒温度罐体压力和参照温度全程采取高限位；SIP失败需要提示Step7:DRAINA1:stopTIMER1&TIMER2andresetdisablePS_CONTROL,disableEN_alarm_T;A2:closeFCV01,setPS_STAtoA3:openFCV08,FCV21,setPA_STA1;(delay10A4:closeFCV21;enableTCT02valveshavebeenvalveshavebeenTIMER1TCT02OrTIMER1isTCT01&TCT02&OrTIMER1isTCT01orTCT02orTIMER2isTIMER1isTCT01&TCT02OrTIMER1isOperatorOperatorA1:closeFCV07;messageSIPSUCCESS; _STAto5;disableEN_alarm_P;A2:resetPA_STA;releaseStep11:CLOSEA1:closeFCV08,FCV14,FCV16,FCV18,FCV20setPA_STAto0;A2:openStep18:JACKA1:messageOPERTORcancloseA1:stopTIMER1&TIMER2disablePS_CONTROL,disableEN_alarm_T;A2:closeFCV01,setPS_STAtoA3:messageoperatorSIPStep16:resetTIMER2A1:stopTIMER2andresetTIMER2Step6:SIPA1:startTIMER2,enableA1:closeFCV01,FCV02,FCV05,FCV12,FCV15,FCV17,FCV19;setTIMER_SP1toTIMER1;setTIMER_SP2toA2:openA3:openFCV01(FCV01baseonA3:setPS_STAto1,enablePS_CONTROL,startStep2:BLOWA1:closeFCV07;setTIMER_SP15toA2:openFCV08,FCV09,FCV10;startStep3:CLOSEA1:closeFCV08;resetA2:openA1:resetTIMER1&TIMER2A1:abortcurrentStep5:CLOSEDRAINandEXHAUSTA1:closeFCV21,FCV07A1:acquireStep10:JACKA1:messageOPERTORcanopenOpenthecompressedairvalvetostartuptiming;withinthetimerpressurereachesup_limit,thetimerisreset,closingallvalves,startsteadytiming,timerisover,steady_pressurenormalend;startkeeptiming,timerisover,keep_pressurenormalend;Iftheupstage,thetimerisover,suggestingfailure,directend;Ifthesteadystage,thepressuredowntothelowerlimit,suggestingfailure,directend;Ifthekeepstage,thepressuredowntothelowerlimit,suggestingfailure,directend;Opentheexhaustat,relief;Step2:PAStep2:PAA1closeFCV01~FCV07,FCV10,FCV12,FCV14~FCV21;setTIMER_SP6toA2openFCV08,FCV09,FCV11,FCV13,;setPA_STAto1;startA1:acquireFCV01~FCV21Keep TIMER1is PCT01< TIMER2isPCT01<TIMER1isStep8:FAILEANDA1:resetStep7:OKANDA1:resetTIMER1;A2:message_STAtoA2:messageKEEPpressureresultisStep11:A1:openFCV07;closeA2:releaseStep6:FAILEANDA1:resetA2:messageKEEPpressureStep4:KEEPA1:closeFCV08,FCV09,FCV11,FCV13resetPA_STAto0A2:resetTIMER1;messageUPFAILEA1:resetTIMER2;setTIMER_SP14toA2:enableA3:startTIMER1,disablevalvesvalveshavebeenPCT01PCT01A1:closeFCV08;resetPA_STAto0;TIMER1;setTIMER_SP12toA2:enableBASE_PT1;set_STAtoA3:startTIMER2,disabledrain罐体排空Openthebottomofthedrain,afterthe levelislessthantheemptyinglimitvalue,delayoffdrain,maintainthenaturalbreathingstate;LCT01<TIMER1isA1:resetTIMER1;closeA2:releaseStep3:PIPEA1:SetTIMER_SP8toA2:startA1:closeFCV08,FCV10,FCV12,FCV15,FCV17,FCV19,FCV20; _STAtoA2:openStep2:A1:acquireDRY罐体吹干Afteropeningthe bottomdrainvalve,openthekeeppressuremode,starttimer,timerisover,closethedrainvalves,the naturallybreathe;打开罐底排放阀，打开保压模式，计时，时间到后关闭排放，罐体自然呼吸valveshavebeenTIMER1isStep4:A1:releaseA1:disablePA_KEEP_P;resetPA_STAto0;resetTIMER1A2:closeFCV08,FCV11,FCV13,FCV14,FCV16,FCV18,FCV21;A3:openStep2:PAA1:closeFCV01~FCV06,FCV10,FCV12,FCV15,FCV17,FCV19,FCV20;setTIMER_SP9toA2:openFCV09,FCV11,FCV13,FCV14,FCV16,FCV18,FCV21;enablePA_KEEP_P;setPA_STAto1;startA1:acquireABORTINGitisdeterminedwhethertheCIPmode,ifso,tostopCIPstation;ifnot,thenJudgmenttemperature,higherthesetvaluestartjacketcoolingtemperature,turnoffthe inletandhydrophobicventvalve,openthebottomofthedrain,afterthepressureislessthantheupperlimitofkeep_pressure,coolinguntilthetemperatureisbelowthesetvaluestartjacketcoolingtemperature;alloftheintermediatestateisinitialized,closeotheroccupiedvalve,retainnaturalbreathing;Iftheoriginalstateisinthe leakdetectionqualified,interruptfunctionwillleadtostatetothehasbeencleaned;Iftheoriginalstateofthe isinoperation,theinterruptfunctionwillcausethe tatetorepairandmaintenance;CIPCIP站；如果不是，判断温度，温度高于启动夹套降温如果原罐体状态处于运行断功能会导致罐状态转为检修、；CIPstationhaveCIPstationhavenotbeenNOTStep2:RELEASECIPA1:ReleaseCIPstation,resetTCT02<= TCT02>_STA_STA_STA<>4_STA Step10:CLOSEA1:resetTIMER1andTIMER2;setPS_STA,PA_STAtodisableEN_alarm_T;disable A2:setCIPVPtocloseroute,closeFCV01~FCV06,FCV08,FCV10~21;openFCV07,FCV09,A3:releaseCIPVP,releaseFCV01~FCV21;Step5:PAA1:openFCV09,enablePA_KEEP_PStep4:DRAINA1:disablePS_CONTROL,EN_alarm_T;resetTIMER1,TIMER2;A3:closeFCV01,FCV03,FCV10,FCV20,setPS_STAto0;A4:openFCV11,Step1:ABORTCIPA1:setP_CIP_ABORT_ORDER;stopSTIR01;resetA2:resetP_CIP_REQUEST_ORDERP_CIP_EN_ConductivityStep7:STATUSEStep8:STATUSEA1:_STAtoA1:_STAtoPAUSINGAccordingtothestateofpause,andclosingthecorrespondingsuspendopenedair,water,inletvalveandCIPstations;inaddition,thesuspendedstateinterlockingwatercontrolblock,cleaningpulsationblock, controlblocktemporarilycontrolvalves,pressurecontrolblockmaintaincontrol.(Inadditiontomanualoperationoutside,cip_p_alarmsignalCIPstationalsoactivatesthepauseNOTCIP_stationnotbeennhasbeenStep7:PAUSCIPA1:setA2:messageCIPNOTNOTStep3:CLOSEA1:closeStep8:STOPA1:stopStep1:CLOSEA1:disablePS_CONTROL;A2:closeFCV01NOTNOTCIP_stationnotbeennhasbeenNOTNOTStep3:OPENA1:openStep8:STARTA1:startStep7:RESTORECIPA1:resetStep1:OPENA1:openDependingonthestateofpause,opentheclosedair,water, inletvalveandCIPrecoverystation;inaddition,theremovalofthesuspendedstateinterlockcontrolblockwater,cleaningpulsationblock,vaporcontrolblock.EM02:BS_EQMEQMClass EQM1.AddWFI2AddWFI3.4.5.Keep6.7.GeneralDescription通用描TheEQMclassisusedtocontroltheBuffer 该设备模块用于缓冲液罐T311002009控制P&IDiagram功能CMTable控制模块DEVICEDescriptionRef2.1CIPWFIWFIWFIPS罐顶罐顶管路分支罐底管路罐底出口前料罐底管路出口罐底出口后料加水脉动启始点（50DEVICEDescription值加水脉动开时间（界面设置2加水脉动关时间（界面设置5点标记位定义----块ParametersTable参数AddWFI0AddWFI限1.5AddWFI限1.2CIP1CIP5CIP1012030121.52.2800.80.6105长300.20.05限0.05555AddWFIAddWFI0AddWFI5AddWFI10600态0为关闭，100温度下限0FlowChart流程AddWFImanAddtomanuallysetthenumberofWFIbythroughWhenaddingwater,openwatervalve,toaddwatermarginissmallerthanthepulseopenpoints,injectionwatersupplyvalvestostartactionaccordingtothepulseofftimeandpulseontime,toaddenoughwater,shutoffthevalveandrespiratortomaintaintheoriginalstate;;通过直通加水添加至人工设定数量的注射水（BATCH中，步前需加操作提示：WFI温度是否满足工艺要求AddWFIDCSTO WFITO valveshavebeenWFIisWFI_DOSEisStep4:A1:disableWFI_DOSE,resetrequireWFI,resetWFI_STA;FCV03,FCV07,FCV08,FCV12,FCV15A2:releaseA1:acquireStep3:addA1:sendW_SP_MANtoA2:enableWFI_DOSE,setWFI_STAto1Step2:BreatheandA1:closeFCV04~FCV06; _STAtoA2:openFCV07;sendWFIrequiretoWFIAddWFILEVELBystraightwateraddtomanuallysettheliquidleveloftheinjectedwater,andtomaintaintheliquidlevel;通过直通加水添加至人工设定液位的注射水，并保持该液位（BATCH中，步前需加操作提示：WFI温度是否满足工艺要求AddWFIDCSTO WFITO valveshavebeenWFIisOpertorStep4:A1:disableWFI_LEVEL,resetrequireWFI,reset(delay5s)A2:closeFCV03,FCV07A3:releaseA1:acquireStep3:addA1:enableWFI_LEVEL,setWFI_STAto1;messageFEEDINGENDSetWFIrequireto0;sendW_SP_MANtoStep2:BreatheandA1:closeFCV04~FCV06; _STAtoA2:openFCV07;sendWFIrequiretoWFICIP罐体IntheCIPlogic,theCleaningfluidisprovidedbyCIPstation,toppass-throughvalveandsprayvalveaccordingtothesettipeneachpulsation,pulsationcycle.在运行阶段，液由CIP站提供。罐顶直通阀门和喷淋阀按设定脉动时间逐个打开，进行循

A1:acquireFCV01~FCV20andCIPVGandStep2:VALVEA1:closeFCV01~FCV03,FCV06,FCV08~FCV11,FCV13,FCV16,FCV17,FCV19,FCV20;A2:openFCV04,FCV05,FCV07,FCV12,FCV14,FCV15,FCV18;sendCIP_TYPEtoStep2:VALVEA1:closeFCV01~FCV03,FCV06,FCV08~FCV11,FCV13,FCV16,FCV17,FCV19,FCV20;A2:openFCV04,FCV05,FCV07,FCV12,FCV14,FCV15,FCV18;sendCIP_TYPEtoP_CIP_PROG_TYPE,CIPVG_ROUTEtohavebeenStep3:CIPStep3:CIPA1:setP_REQUEST_ORDER,P_CIP_START_ORDER,P_CIP-PUMP_AIR_SUPPLY-ORDERP_CIP_EN_ConductivityP_CIP_RETURNPUMP_ORDER,P_CIP-EN_TIMER;enable UP_PUSLCIP_P_

A1:setA1:set

A1:setDRAIN_CTRL,sendSP13toTIMER2A2:setP_CIP_PAUSE_ORDER,startTIMER2Step6:CIPA1:disableStep6:CIPA1:disable UP_PUSLA2:closeFCV01~FCV20,setCIPVGtocloserouteA1:resetA2:reset

NOTStep7:CIPStep7:CIPA1:MessageSUCCESS, 1_STAtoA2:resetP_REQUEST_ORDER,P_CIP_START_ORDER,PUMP_AIR_SUPPLY-ORDER,P_CIP_EN_ConductivityStep8:CIPA1:resetP_REQUEST_ORDER,P_CIP_START_ORDER,PUMP_AIR_SUPPLY-ORDER,P_CIP_EN_ConductivityA2:MessageFAIL

A1:A1:ReleaseFCV01~FCV20;releaseCIPPVGandCIP

IPInIntheSIPlogic,theclean injectionintothevesseltoheating.Thevesseltemperature,theventfilterdraintemperature,thevesseldraintemperaturewillbemonitored,whenthesethreetemperatureatthesametimetoreachedsterilizationtemperatureforaperiodtime,thenthesterilizationissuccessful.Ifanytemperatureislowerthesterilizationtemperature,thenthesterilizationtimerisstop,untilthetemperatureisok,thesterilizationtimerisresetandrestart.3个温度同时达到灭菌温度且持续一段时间后，才认为灭菌成功。在灭菌过程中，如果任何一个温lyrespiratortopurgethewaterfilm,andthensterilizedbyheating;Sterilizationheatingstage, bottomvalveandexhaustvalveopensuntilitreachesthesettemperature;aftersterilizationtime,pure forthe valveinthe pressureorhigherthanthehighestreferencetemperature(threelowesttemperaturevalue)ishigherthanthetemperatureoffvalvecapclosed,thereferencetemperatureislessthanthelowerlimitofthetemperatureofthevalveopeningopen;Afterthesterilizationprocess,closethetrapdischargerespirator, bottomremainsopen;openthecompressedairvalve, bottomdischargeopeningonly10seconds;whenthebodytemperaturedropsopenjacketcoolanttemperaturepoint,indicatingoperativesjacketcoolingoperation;waitforthetemperaturetocooldownagainwhenthetemperatureof point,Buckexhausttodwelllimit,closedmouthaftercleaning bottomand bottomdrainvalvedischargerefrigerantprompttheoperatortoclosethejacket,end.Referringto pressureandtemperaturetakefullhighlimitalarm;SIPfailureneed10秒；当罐体温度降到开启夹套冷媒温度罐体压力和参照温度全程采取高限位；SIP失败需要提示valveshavebeenTIMER1TCT02OrTIMER1isTCT01&TCT02&OrTIMER1isTCT01orTCT02orTIMER2isTIMER1isTCT01&TCT02OrTIMER1isOperatorA1:closeFCV09,FCV15,FCV17,FCV19setPA_STAto0messageOPERTORcloseA2:openFCVO8 TCT02A1:closemessageSIP _STAto5;disableEN_alarm_P;A2:resetPA_STA;releaseFCV01~FCV20Step10:JACKA1:messageOPERTORcanA1:stopTIMER1&TIMER2disablePS_CONTROL,disableEN_alarm_T;A2:closeFCV01,setPS_STAtoA3:messageoperatorSIPStep7:DRAINA2:stopTIMER1&TIMER2andresetdisablePS_CONTROL,disableEN_alarm_T;A3:closeFCV01,setPS_STAtoA4:openFCV09,FCV20,setPA_STAto1;(delay10s)A5:closeFCV20;enableStep16:resetTIMER2A1:stopTIMER2andresetTIMER2Step6:SIPA1:startTIMER2,enableA1:closeFCV01,FCV02,FCV03,FCV06,FCV13,FCV16,FCV18A2:openA3:enablePS_CONTROL,setTIMER_SP1toTIMER1A4:setPS_STAto1,startStep2:BLOWA1:closeFCV08;setTIMER_SP15toTIMER1A2:openFCV09,FCV10,FCV11;startTIMER1;Step3:CLOSEA1:closeFCV09;resetA2:openA1:resetTIMER1&TIMER2A1:abortcurrentStep5:CLOSEDRAINandA1:closeFCV20,FCV08,setTIMER_SP2toA1:acquireKeepPressureOpenthecompressedairvalvetostartuptiming;withinthetimerpressurereachesup_limit,thetimerisreset,closingallvalves,startsteadytiming,timerisover,steady_pressurenormalend;startkeeptiming,timerisover,keep_pressurenormalIftheupstage,thetimerisover,suggestingfailure,directend;Ifthesteadystage,thepressuredowntothelowerlimit,suggestingfailure,directend;Ifthekeepstage,thepressuredowntothelowerlimit,suggestingfailure,directend;Opentheexhaustat,relief;Step2:PAStep2:PAA1closeFCV01~FCV08,FCV11,FCV13,FCV15~FCV20;setTIMER_SP6toA2openFCV09,FCV10,FCV12,FCV14,;setPA_STAto1;startA1:acquireFCV01~FCV20Keep TIMER1is PCT01< TIMER2isPCT01<TIMER1isStep8:FAILEANDA1:resetStep7:OKANDA1:resetTIMER1;A2:message_STAtoA2:messageKEEPpressureresultisStep11:A1:openFCV08;,FCV10,FCV12,FCV14;closeA2:releaseStep6:FAILEANDA1:resetA2:messageKEEPpressureStep4:KEEPA1:closeFCV09,FCV10,FCV12,FCV14resetPA_STAto0A2:resetTIMER1;messageUPFAILEA1:resetTIMER2;setTIMER_SP14toA2:enableA3:startTIMER1,disablevalvesvalveshavebeenPCT01PCT01A1:closeFCV09;resetPA_STAto0;TIMER1;setTIMER_SP12toA2:enableBASE_PT1;set_STAtoA3:startTIMER2,disabledrain罐体排空Openthebottomofthedrain,aftertheliquidlevelislessthantheemptyinglimitvalue,delayoffdrain,maintainthenaturalbreathingstate;valveshavebeen DRAINA1:closeFCV01~FCV07,FCV09,FCV11,FCV13,FCV16,FCV18,FCV19;A2:open_STAtoLCT01<TIMER1isA1:resetTIMER1;closeA2:releaseStep3:PIPEA1:SetTIMER_SP8toA2:startA1:acquireDRY罐体吹干Afteropeningthe bottomdrainvalve,openthekeeppressuremode,starttimer,timerisover,closethedrainvalves,the naturallybreathe;打开罐底排放阀，打开保压模式，计时，时间到后关闭排放，罐体自然呼吸valveshavebeenTIMER1isStep4:A1:releaseA1:disablePA_KEEP_P;resetPA_STAto0;resetTIMER1A2:closeFCV13,FCV14,FCV15,FCV17,FCV20,FCV09;A3:openStep2:PAA1:closeFCV01~FCV07,FCV11,FCV13,FCV16,FCV18,FCV19;setTIMER_SP9toA2:openFCV10,FCV12,FCV14,FCV15,FCV17,FCV20;enablePA_KEEP_P;setPA_STAto1;startA1:acquireABORTINGitisdeterminedwhethertheCIPmode,ifso,tostopCIPstation;ifnot,thenJudgmenttemperature,higherthesetvaluestartjacketcoolingtemperature,turnoffthe inletandhydrophobicventvalve,openthebottomofthedrain,afterthepressureislessthantheupperlimitofkeep_pressure,coolinguntilthetemperatureisbelowthesetvaluestartjacketcoolingtemperature;alloftheintermediatestateisinitialized,closeotheroccupiedvalve,retainnaturalbreathing;Iftheoriginalstateisinthe leakdetectionqualified,interruptfunctionwillleadtostatetothehasbeencleaned;Iftheoriginalstateofthe isinoperation,theinterruptfunctionwillcausethe tatetorepairandmaintenance;CIPCIP站；如果不是，判断温度，温度高于启动夹套降温如果原罐体状态处于运行断功能会导致罐状态转为检修、；CIPstationhaveCIPstationhavenotbeenNOTStep2:RELEASECIPA1:ReleaseCIPTCT02<= TCT02>_STA_STA_STA<>4_STA Step10:CLOSEA1:resetTIMER1andTIMER2;setPS_STA,PA_STAtodisableEN_alarm_T;disable A2:setCIPVPtocloseroute,closeFCV01~FCV07,FCV09,FCV11~20;openA3:releaseCIPVP,releaseFCV01~FCV20_STAtoA1:Step7:STATUSEStep5:PAA1:openFCV09,enablePA_KEEP_PA2:setPA_STAto1Step4:EXHAUSTA1:disablePS_CONTROL,EN_alarm_T;resetTIMER1,TIMER2;A3:closeFCV01,FCV04,FCV11,FCV19,setPS_STAto0;A4:openFCV12,Step1:ABORTCIPA1:setA2:resetP_CIP_REQUEST_ORDERP_CIP_EN_Conductivity;Step8:STATUSEA1:_STAtoPAUSINGAccordingtothestateofpause,andclosingthecorrespondingsuspendopenedair,water,inletvalveandCIPstations;inaddition,thesuspendedstateinterlockingwatercontrolblock,cleaningpulsationblock, controlblocktemporarilycontrolvalves,pressurecontrolblockmaintaincontrol.(Inadditiontomanualoperationoutside,cip_p_alarmsignalCIPstationalsoactivatesthepauseStep1:CLOSEA1:disableA2:Step1:CLOSEA1:disableA2:closeFCV01NOTStep3:CLOSEA1:closeNOTNOTStep7:PAUSCIPA1:setA2:messageCIPStep5:CLOSEA1:disableNOTCIP_stationnotbeennhasRESTOREDependingonthestateofpause,opentheclosedair,water, inletvalveandCIPrecoverystation;inaddition,theremovalofthesuspendedstateinterlockcontrolblockwater,cleaningpulsationblock,vaporcontrolblock.Step1:OPENA1:openNOTStep3:OPENStep1:OPENA1:openNOTStep3:OPENA1:openNOTNOTStep7:RESTORECIPA1:resetStep5:OPENA1:enableNOTCIP_stationnotbeennhasEM03:EQMEQMClassEQM1.2.3.DefinedGeneralDescription通用描TheEQMclassisusedtocontroltheSTIRof该设备模块用于罐的搅拌控制P&IDiagram功能CMTable控制模块ParametersTable参数Start/Dfined10010FlowChart流程Stopaborting)停止(中断Switchingtoautomaticmode,sendingstopsignal;interruptalsoperformsstopoperation;(Exceptstophumanoperator,underthelowerofthe liquidlevelwilldirectlyinterlockstop);（除操作工人为停止外，液位的下下限也会直接联锁搅拌停止A1:stopA2:setSTIRmodetoStep1:MODE*1)A1:setSTIRmodeto*1)Ax:x=1,2,3…thenumberrepresenttheaction’sexecutesequence,whieansthenextactiondosenotbeexecutedbeforethepreviousactioncompleydone.StartChangworkmodeofstirtoautomode,sendoutstartA1:setRPMtoRPM_SPA2:startSTIRStep1:MODEA1:setSTIRmodetoDfinedSwitchingmodetoautomatically,transstartsignal,startthetimer,timerisover,stopstir.whentimerisrunning,stirisinterlockedtostoped,thentheprogramisendbyautomatically;STIRSTIRTIMERisOrNOTA1:setTIMER1_SPtoA2:startA1:setRPMtoRPM_SPA2:startSTIRStep1:MODEA1:setSTIRmodetoStep4:resetTIMERA1:resetTIMERA2:stopSTIRA3:setSTIRmodetoEM04:EQMEQMClassEQM1.2.Trans3.TransGeneralDescription通用描TheEQMclassisusedtocontrolroutebetweenbuffer andtransfer该设备模块用于缓冲液罐和转接板之间的路径控制P&IDiagram功能TRANS（examples:T311002021—TRANSCIP（examples:T311002021—TRANSSIP（examples:T311002021—CMTable控制模块DEVICEDescriptionRef2.1CIPPS罐顶阀前料罐顶罐顶管路分支罐底管路分支阀罐底管路分支阀罐底管路罐底出口前料罐底管路出口罐底出口后料转料路径开阀转料路径开阀转料路径开阀转料路径开阀转料路径开阀转料路径关阀TPTPDEVICEDescriptionTPTP同时用作CIP站的点灭菌时蒸汽控制块DEVICEDescriptionRef2.1CIPPS罐顶阀前料罐顶罐顶管路分支罐底管路分支阀罐底管路分支阀罐底管路罐底出口前料罐底管路出口罐底出口后料转料路径开阀转料路径开阀转料路径开阀转料路径开阀转料路径开阀转料路径关阀TPTPDEVICEDescriptionTPTP同时用作CIP站的点灭菌时蒸汽控制块DEVICEDescriptionRef2.1CIPPS罐顶