PF-03463275-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEPF-03463275Cat.No.:HY-10716ACASNo.:1173239-39-8分⼦式:C₁₉H₂₂ClFN₄O分⼦量:376.86作⽤靶点:GlyT作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:33.33mg/mL(88.44mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.6535mL13.2675mL26.5351mL5mM0.5307mL2.6535mL5.3070mL10mM0.2654mL1.3268mL2.6535mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥0.83mg/mL(2.20mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥0.83mg/mL(2.20mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥0.83mg/mL(2.20mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性PF-03463275⼀种中枢神经系统渗透性、具有⼝服活性、选择性、竞争性⽢氨酸转运蛋⽩-1(GlyT1)可逆抑制剂，Ki为11.6nM。PF-03463275有可能⽤于精神分裂症的研究。体内研究PF-03463275(1-10mg/kg;s.c.)attenuatesoscillatorypotentials(OPs)[2].AnimalModel:MaleSprague-Dawleyrats[2]Dosage:1,3and10mg/kgAdministration:S.c.Result:Adose-dependentreductionintheamplitudeofoscillatorypotentials(OPs)elicitedfromthedark-adaptedrats.REFERENCES[1].LoweJA3rd,etal.Thediscoveryofastructurallynovelclassofinhibitorsofthetype1glycinetransporter[publishedcorrectionappearsinBioorgMedChemLett.2009Aug15;19(16):4885.Bronk,BrianS[added];Schaeffer,Eric[added]].BioorgMedChemLett.2009;19(11):2974-2976.[2].LiuCN,PettersenB,SeitisG,OsgoodS,SompsC.GlyT1inhibitorreducesoscillatorypotentialsoftheelectroretinograminrats.CutanOculToxicol.2014;33(3):206-211.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: