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GeneralOverviewofDetectorSystemsDanielaCavagninoGeneralOverviewofDetectorSDetectorsclassificationUniversalTheyrespondtoeverythingelutingfromthecolumnTCDPDD(FID)SelectiveTheymaybeelementselective,structure/functionalgroupselectiveorselectivetootherpropertiesFID(verybroad
selectivity)ECDPIDPDDSpecificTheyaresoselectivetodistinguishparticularstructuresorelementsNPDFPDDetectorsclassificationUniverConcentrationvsMassdependentresponseCommonconc.dependent:TCDPIDPDDECDCommonmassdependent:FIDNPDFPDNon-DestructivevsDestructiveCommonnon-destructive:TCDPIDPDDECDCommondestructive:FIDNPDFPDDetectorsclassificationConcentrationvsMassdependenDetectorResponseCharacteristicsSensitivityDetectorefficiencytoconvertthesampleinanelectricalsignalNoiseShortterm:highfrequencybaselinefluctuationLongterm:lowfrequencybaselineperturbationDynamicRangeRangeofsampleconcentrationforwhichthedetectorcanprovideadetectablesignalvariationwithanalyteamountSelectivityTheratioofthedetectorsensitivitiesofagivencompoundoverapotentiallyinterferingcompoundMinimumDetectabilityAmountofsampleinwhichthepeakheightis3timesthenoiseheight(S/N=3)DetectorResponseCharacteristDetectorResponseCharacteristics
SensitivityandMinimumDetectabilityFIDsensitivity:S===coulomb/g=FPDsensitivityforsulfur:S=*=uV/(gS/s)2MDA===g/secRF(ResponseFactor)=MDA==gS/secpeakareasampleweightA*secgpeakareaSamountPW½Samount3NSA*gA*secpeakareaamount3NSpeakheightmassraten-1½DetectorResponseCharacterist
DynamicandLinearRangeDynamicrange:overwhich
anincrementalchangeinthe
amountofcompoundsinthe
detectorvolumeproducesa
measurableincremental
changeinthedetectorsignalLinearrange:overwhich
theresponsedeviationisless
than5%DetectorResponseCharacteristicsDynamicandLinearRangeDyFlameIonizationDetectorUniversalresponseIonizationdetectionMassdetectorDestructiveFlameIonizationDetectorUnivFlameIonizationDetectorHydrogenismixedwithgasstreamatbottomofjetandairoroxygenissuppliedaxiallyaroundthejetHydrogenflameburnsatthetip,whichalsofunctionsascathodeanditiselectricallyinsulatedfromthebodyCollectorelectrodeisabovetheburnertipFlameIonizationDetectorHydroFlameIonizationDetectorPrincipleofoperationCombustionof
organiccompoundsina
oxidizingflameCH+OCHO++e-Electricfieldbetween
thejetandthecollector
electrodeVoltage-300VCollectionofthe
ionsgeneratedinto
theflameCurrentpAAgoodcombustionstepistheprevailingfactortogetthebestperformancesFlameIonizationDetectorPrincFlameIonizationDetectorItrespondstoallorganiccompoundsexceptforformicacidResponseisgreatestwithhydrocarbonsanddecreaseswithsubstitutionSensitivityhighduetolownoiselevelNoresponsetowater,permanentgases,andinorganiccompoundssimplifiestheresolutionofcomponentsinanalysisofaqueousextractsandinairpollutionstudiesSuitableforfastandultrafastGCapplicationsFlameIonizationDetectorItrFlameIonizationDetectorTechnicalSpecifications
Operatingtemperaturelimit 450°CwithceramicjetLinearrange betterthan106
Minimumdetectableamount 3x10-12gC/sInputrange 0to10-6AInputattenuation 4steps(100-101-
102-
103)Electrodepolarizationvoltage -300VTimeconstant 6ms@63.2%Acquisitionrate upto300HzFlameIonizationDetectorTechnFlameIonizationDetectorStandardOperatingProcedure(SOP)C12C14C16AreaCounts>4000000C12=6877493C14=6790762C16=6988181FlameIonizationDetectorStandFlameIonizationDetectorMDLCalculation(C12)C12C14C16V=1.6uL@20ng/uLMassC12=32ng%C=84.7%MassC=27.1ngC12A=6877493(0.1uV*s)MDL=3N/S
S=Area(uV*s)/mass
MDL=48(uV)*27.1(ngC)/687749.3(uV*s)=0.00189ngC/s=1.89pgC/sNoise16uVFlameIonizationDetectorMDLCElectronCaptureDetectorSelectiveresponseNon-destructiveIonizationdetectorprincipleConcentration-dependentdetectorRadioactivesource63Ni(10mCiactivity)Displacedcoaxial-cylindergeometryElectronCaptureDetectorSelecPrinciplesofdetectionElectronCaptureDetector---e-e-+++-MMMABAB_+*+N2 +N2++e-*+Ar +Ar++e-+Ar*Ar*+CH4 Ar+e-+CH4+dissociative-capturemechanismAB+e- A·+B-nondissociativemechanismAB+e- AB-sidereactionsC+e- C-N2++e- neutralsAB-+N2+ neutralsPrinciplesofdetectionElectrElectronCaptureDetectorPulsedvoltage[e-]V500TTime(s)w=0.11sPULSEvoltageDCvoltageElectronCaptureDetectorPulse
ElectronCaptureDetectorConstantcurrentmethodI=Ke-]f+-Iff=constI=constElectronCaptureDetectorConsConstantcurrentmethodModulationofPulseFrequencyioncurrent=electronsconcentrationxpulsefrequencywithnosample freq.=f°withelectronegativesample freq.=fssignaloutput=fs-f°=sampleconcentrationElectronCaptureDetectorConstantcurrentmethodModulatElectronCaptureDetectorRadioactivesource: Nickel63–370MBq(10mCi)Cellvolume 450LOperatingtemperaturelimit: 400°CMinimumdetectableamount: 10fgoflindaneLineardynamicrange: 104(argon/methane)
103(nitrogen)Operationmode: constantcurrentpulse-modulatedmodeReferencecurrent: 0to3nA(0.1nAsteps)Pulseamplitude: 5to50Vneg.Pulsewidth: 0.1s(argon/methane),
0.5s,1s(nitrogen)TechnicalSpecificationsElectronCaptureDetectorRadioElectronCaptureDetectorMolecularfeaturesgoverningtheresponseofECDLowresponseforalcohols,amines,phenols,aromaticsandvinyl
typefluorinatedhydrocarbonsHighresponseforhalocarboncompounds,nitroaromatics,and
conjugatedcompoundscontainingtwogroupswhichindividually
arenotstronglyelectronattractingbutbecomesowhen
connectedbyspecificbridgesResponsetowardsthehalogensdecreasesintheorderI>Br>Cl>FElectronCaptureDetectorMolecElectronCaptureDetectorMolecularfeaturesgoverningtheresponseofECDMultiplesubstitutionwithsimpleelectronattractinggroupsor
atomsmayincreasethemolecularabsorptionbyanamountmuch
greaterthanexpectedofasimpleadditiveeffectTheabsorptionconferredbyasimpleelectrophoricgroupisalso
sensitivetothepositioninthemoleculeSomeinorganiccompoundsareelectronabsorbers,ascarbon
disulfide,ozoneandtheoxidesofnitrogenElectronCaptureDetectorMolecElectronCaptureDetectorRelativesensitivityEthaneBenzene 1ButanolAcetoneChlorobutane 1-102Chlorobenzene1,2-dichlorobenzeneAntracene 102-104ChloroformNitrobenzene 104-105CarbontetrachlorideDinitrophenolDiethyloxalate 105-106DihydropyridineInfluenceofdetectortemperatureDetectionlimit(x10-9g)CCl4 0.010.010.01CHCl31.00.10.05CH2Cl21000408CH2ClCH2Cl1000201
80°C227°C350°CElectronCaptureDetectorRelatElectronCaptureDetectorRelativeresponseofhalocarbonsCF3CF2CF3 1.0CF3Cl 3.3CF2=CFCl 100CF3CF2Cl 170CF2=CCl2 670CF2Cl2 3x104CHCl3 3.3x104CHCl=CCl2 6.7x104CF3Br 8.7x104CF2ClCFCl2 1.6x105CF3CHClBr 4.0x105CF3CF2CF2I 6.0x105CF2BrCF2Br 7.7x105CFCl3 1.2x106ElectronCaptureDetectorRelatg-LINDANEMDA=10fgwithS/N=3ALDRIN(15pg)HEPTACHLOR(10pg)g-LINDANE(10pg)x2x64ECDperformanceMinimumDetectableAmountg-LINDANEMDA=10fgwithSBestconditionsforECDsensitivity
ECDsensitivityisaffectedbythefollowingfactors:
Referencecurrent
Thehigheristhereferencecurrent,thegreateristhesignalresponsebut
alsothebaselinenoise.TheS/Nrationeedstobedeterminedfor
sensitivityevaluation
Ionizinggas(makeup)
TheECDisaconcentration-dependentdetector.Theloweristhemakeup
flowrate(upto15-20mL/min),thehigheristheresponse.
Argon/methaneasmakeupgasallowstooperateatlowerfrequencies
whileusinghigherreferencecurrentsetting
Detectortemperature
Forsomecompoundsthesensitivitywillincreasewiththecelltemperature
(dissociativemechanismofreaction)BestconditionsforECDsensitECDperformanceLinearityECDperformanceLinearityBestconditionsforECDlinearity
ECDlinearityisverydependantuponseveralfactors:
ECDconditions
PulseVoltage:lowestisbetter(upto15V)accordingtotheoutputfreq.
Basefrequency:mustbearound1KHz
ReferenceCurrent:itcanbereducedto0.7-0.8nAifnecessary
Ionizinggas(makeup)–Argon/methane:assurethewidest
linearityrange
Nitrogen:shouldbeusedunderclean
conditionswith0.5usofPulseWidth
Inbothcasestheflowratecanbeincreasedto40-45mL/minformaintainingalowbasefrequency
Carriergas–Hydrogen:linearrangeuptoabout100pg
Helium:sligthlybetterthanhydrogen
Nitrogen:linearrangeshifteduptoabout200pgThecompletesystemincludingthegassupplylinesandgaseshavetobeverycleantoachievealowbasefrequencyBestconditionsforECDlinearElectronCaptureDetectorStandardOperatingProcedureSOPLindaneAldrinNoise73uV(10VFS)S/N>4000Lindane=4820Aldrin=4431ElectronCaptureDetectorStandElectronCaptureDetectorLindaneAldrinNoise73uV(10VFS)V=1.6uL@30pg/uLMassLindane=48pgLindaneA=6122928(0.1uV*s)MDL=3N/S
S=Area(uV*s)/mass
MDL=219(uV)*48(pg)/612292.8(uV*s)=0.0172pg/s=17fgLindane/sMDLCalculation(Lindane)ElectronCaptureDetectorLindaElectronCaptureDetectorMultiplesimultaneousdetectionFID,NPDorFPD
stackedonECDElectronCaptureDetectorMultiAirColumneffluent+Hydrogen/MakeupHeatedsource(Rbceramicmatrix)CollectingelectrodeNitrogenPhosphorousDetector
SpecificresponsevsNandP
organiccompoundsIonization-typedetectorMassdetectorDestructiveRbceramicbeadasthermionic
ionizationsourceAirColumneffluent+Hydrogen/Sampledecomposition®Electronegativeproducts(e.g.NO2,CN,PO2)2+Hotsource®NegativeionsElectronegativespeciesNPD:detectionmechanismTID-2(BlackSource)SampledecompositiSample®Electronegativedecompositionproducts+Hotsource®NegativeionsElectronegativespecies2ENSmode:detectionmechanismTID-1(WhiteSource)Sample®ElectronegativedecoNPDmode:newglassbeadCanreplaceTID-2sourceHigherresponsefor
Phosphorouscompounds
(…buttailingpeakscanbe
observed)Loweroperatingcurrent:
extendedlifetimeSameflowratessettingas
TID-2Blos-Source(GlassBead)NPDmode:newglassbeadCanrThethermionicsourceelementisaconsumablecomponentthatmustbereplacedperiodicallyEasilyinterchangeablethermionicsourcesThermionicsourcelifetimeisstrictlydependentontheoperativeconditions.
NitrogenPhosphorousDetectorThethermionicsourceelementTechnicalSpecificationsOperatingtemperaturelimit 450°CLinearrange betterthan104
Minimumdetectableamount 5x10-2pgN/s 2x10-2pgP/sSelectivity N/C=105:1 P/C=2x105:1Inputrange 0to10-6AInputattenuation 4steps(100-101-
102-
103)Heatingcurrentsetting1.00to3.50Ain0.01stepPolarizationvoltagesetting1.0to9.9Vin0.1stepNitrogenPhosphorousDetectorTechnicalSpecificationsOperNitrogenPhosphorousDetectorStandardOperatingProcedureSOPAzobenzeneMethylparathionAreaCounts
>1500000(Azobenzene)
>3000000(Methylparathion)Azobenzene=1598004Methylparathion=4688635NitrogenPhosphorousDetectorSNitrogenPhosphorousDetectorAzobenzeneMethylparathionMDLCalculation(Azobenzene)V=1.6uL@1ng/uLMassAzobenzene=1.6ng
%N=15.3%
MassN=0.244ngazobenzeneA=1598004(0.1uV*s)MDL=3N/S
S=Area(uV*s)/mass
MDL=54(uV)*0.244(ngN)/159800.4(uV*s)=8.24E-5ngN/s=8.2E-2pgN/sNoise18uVNitrogenPhosphorousDetectorAFlamePhotometricDetectorspecificresponsevsSorP
compoundsdestructivelight-emissiondetectionmassdetectorsingle-flamedesigndualparallelconfigurationFlamePhotometricDetectorspFlamePhotometricDetectorPrincipleofoperationSulphurcompoundsH2S+HHS+H2HS+HS+H2S+SS2*S+S+MS2*S2*S2+hQuadraticresponseforsulfurcompounds!PhosphorouscompoundsPO+H+MHPO*+MPO+OH+H2HPO*+H2OHPO*HPO+hFlamePhotometricDetectorPrinFlamePhotometricDetectorChemiluminescentemissionspectraofsulfurandphosphorouscompoundsinhydrogen-richflameEmissionsignalWavelength(nm)Wavelength(nm)Sulfur(S2*)Phosphorous(HPO*)FlamePhotometricDetectorChemFlamePhotometricDetectorTheemissionofexcitedmoleculesismeasuredagainst
someflamebackgroundbymeansofnarrowbandpass
interferenceopticalfilters:S394nmP526nmSn610nmFlamePhotometricDetectorThFlamePhotometricDetectorNon-linearresponseinsulfur-selectivedetection
Intensityofthesulfuremission:
I[S]nlog[S]1/nlogI
theexponentialfactornistheoreticallyequalto2itisdependentupontheFPDoperatingconditionsitisstronglycompounddependentitisexperimentallydeterminedFlamePhotometricDetectorNon-FlamePhotometricDetectorQuenchingeffectinsulfur-selectivedetection
collisionalquenchingofS2*byCO2,CH4,andother
combustionproductsreducesthesulfurresponsehydrocarbonsareparticularlyeffectiveinquenchingthe
sulfurresponseincaseofcoelutionathighconcentrations,quenchingeffectmaybe
observed,leadingtoacurvatureofthecalibrationcurveFlamePhotometricDetectorQuenFlamePhotometricDetectorTheoptimumairflowrateshouldbeexperimentallydeterminedafter
correctsettingofthehydrogenflowrateVariationsintheair/hydrogenratioleadtodeviationsfromthe
sulfurquadraticresponseWhenoperatinginphosphorousmode,variationsintheair/hydrogen
ratiocanstronglyaffecttheresponseforcertainphosphorous
compoundswhiletiophosphatesareunaffectedThepositionofthecolumnendisespeciallycritical,sincemost
compoundscontainingsulfurandphosphorousareveryactiveThephotomultipliertubenoiseincreaseswithincreasingdetector
temperatureByincreasingtheH2/airratio,thenegativeresponseofHCdecreaseandalsotheScompoundstailingdecreasesPracticalhintsFlamePhotometricDetectorTFlamePhotometricDetectorMaintainingandtroubleshooting
ifahighnoiseandstandingcurrentisobserved,itcanbedueto:
-columnbleeding-opticalsystemnotlight-tight-toohightemperaturenearthephotomultipliertubeiflowsensitivityisobserved,itcanbedueto: -hydrogenflowratetoolow
-airflowratetoohigh -reducedopticalclarityonopticalwindowstopreventdamagingthephotomultipliertube,avoidanyexposuretolight,
evenforshortperiod,whenpoweredon.FlamePhotometricDetectorMainFlamePhotometricDetectorTechnicalSpecificationsFPDtemperaturelimit 350°CSulfurfilter 394nmPhosphorousfilter 526nmDetectionlimit Sulfur5x10-12gS/s(Parathion) Phosphorous1x10-13gP/s(Parathion)Selectivity S/hydrocarbon105 P/hydrocarbon106Linearrange 103forSulfurafterlinearization 104forPhosphorousPhotomultiplierTubeVoltageselectableto800V(low)
and900V(high)FlamePhotometricDetectorTechFlamePhotometricDetectorStandardOperatingProcedureSOP(Sfilter394nm)S/N>40S/N=73MethylparathionNoise213uVFlamePhotometricDetectorStanFlamePhotometricDetectorMethylparathionNoise213uVMDLCalculation(Sfilter394nm)V=1.6uL@1ng/uLMassMethylparathion=1.6ng
%S=12.1%
MassS=0.194ngMethylparathionA=257001(0.1uV*s)MDL=(3N/S)½
S=(Area(uV*s)/mass)*(PW½/mass)S=
25700(uV*s)/194(pgS)*1.34(s)/194(pgS)
=0.91uV/(pgS/s)2
MDL=(639(uV)/0.91)½=26.5pgS/sFlamePhotometricDetectorMethGeneralOverviewofDetectorSystemsDanielaCavagninoGeneralOverviewofDetectorSDetectorsclassificationUniversalTheyrespondtoeverythingelutingfromthecolumnTCDPDD(FID)SelectiveTheymaybeelementselective,structure/functionalgroupselectiveorselectivetootherpropertiesFID(verybroad
selectivity)ECDPIDPDDSpecificTheyaresoselectivetodistinguishparticularstructuresorelementsNPDFPDDetectorsclassificationUniverConcentrationvsMassdependentresponseCommonconc.dependent:TCDPIDPDDECDCommonmassdependent:FIDNPDFPDNon-DestructivevsDestructiveCommonnon-destructive:TCDPIDPDDECDCommondestructive:FIDNPDFPDDetectorsclassificationConcentrationvsMassdependenDetectorResponseCharacteristicsSensitivityDetectorefficiencytoconvertthesampleinanelectricalsignalNoiseShortterm:highfrequencybaselinefluctuationLongterm:lowfrequencybaselineperturbationDynamicRangeRangeofsampleconcentrationforwhichthedetectorcanprovideadetectablesignalvariationwithanalyteamountSelectivityTheratioofthedetectorsensitivitiesofagivencompoundoverapotentiallyinterferingcompoundMinimumDetectabilityAmountofsampleinwhichthepeakheightis3timesthenoiseheight(S/N=3)DetectorResponseCharacteristDetectorResponseCharacteristics
SensitivityandMinimumDetectabilityFIDsensitivity:S===coulomb/g=FPDsensitivityforsulfur:S=*=uV/(gS/s)2MDA===g/secRF(ResponseFactor)=MDA==gS/secpeakareasampleweightA*secgpeakareaSamountPW½Samount3NSA*gA*secpeakareaamount3NSpeakheightmassraten-1½DetectorResponseCharacterist
DynamicandLinearRangeDynamicrange:overwhich
anincrementalchangeinthe
amountofcompoundsinthe
detectorvolumeproducesa
measurableincremental
changeinthedetectorsignalLinearrange:overwhich
theresponsedeviationisless
than5%DetectorResponseCharacteristicsDynamicandLinearRangeDyFlameIonizationDetectorUniversalresponseIonizationdetectionMassdetectorDestructiveFlameIonizationDetectorUnivFlameIonizationDetectorHydrogenismixedwithgasstreamatbottomofjetandairoroxygenissuppliedaxiallyaroundthejetHydrogenflameburnsatthetip,whichalsofunctionsascathodeanditiselectricallyinsulatedfromthebodyCollectorelectrodeisabovetheburnertipFlameIonizationDetectorHydroFlameIonizationDetectorPrincipleofoperationCombustionof
organiccompoundsina
oxidizingflameCH+OCHO++e-Electricfieldbetween
thejetandthecollector
electrodeVoltage-300VCollectionofthe
ionsgeneratedinto
theflameCurrentpAAgoodcombustionstepistheprevailingfactortogetthebestperformancesFlameIonizationDetectorPrincFlameIonizationDetectorItrespondstoallorganiccompoundsexceptforformicacidResponseisgreatestwithhydrocarbonsanddecreaseswithsubstitutionSensitivityhighduetolownoiselevelNoresponsetowater,permanentgases,andinorganiccompoundssimplifiestheresolutionofcomponentsinanalysisofaqueousextractsandinairpollutionstudiesSuitableforfastandultrafastGCapplicationsFlameIonizationDetectorItrFlameIonizationDetectorTechnicalSpecifications
Operatingtemperaturelimit 450°CwithceramicjetLinearrange betterthan106
Minimumdetectableamount 3x10-12gC/sInputrange 0to10-6AInputattenuation 4steps(100-101-
102-
103)Electrodepolarizationvoltage -300VTimeconstant 6ms@63.2%Acquisitionrate upto300HzFlameIonizationDetectorTechnFlameIonizationDetectorStandardOperatingProcedure(SOP)C12C14C16AreaCounts>4000000C12=6877493C14=6790762C16=6988181FlameIonizationDetectorStandFlameIonizationDetectorMDLCalculation(C12)C12C14C16V=1.6uL@20ng/uLMassC12=32ng%C=84.7%MassC=27.1ngC12A=6877493(0.1uV*s)MDL=3N/S
S=Area(uV*s)/mass
MDL=48(uV)*27.1(ngC)/687749.3(uV*s)=0.00189ngC/s=1.89pgC/sNoise16uVFlameIonizationDetectorMDLCElectronCaptureDetectorSelectiveresponseNon-destructiveIonizationdetectorprincipleConcentration-dependentdetectorRadioactivesource63Ni(10mCiactivity)Displacedcoaxial-cylindergeometryElectronCaptureDetectorSelecPrinciplesofdetectionElectronCaptureDetector---e-e-+++-MMMABAB_+*+N2 +N2++e-*+Ar +Ar++e-+Ar*Ar*+CH4 Ar+e-+CH4+dissociative-capturemechanismAB+e- A·+B-nondissociativemechanismAB+e- AB-sidereactionsC+e- C-N2++e- neutralsAB-+N2+ neutralsPrinciplesofdetectionElectrElectronCaptureDetectorPulsedvoltage[e-]V500TTime(s)w=0.11sPULSEvoltageDCvoltageElectronCaptureDetectorPulse
ElectronCaptureDetectorConstantcurrentmethodI=Ke-]f+-Iff=constI=constElectronCaptureDetectorConsConstantcurrentmethodModulationofPulseFrequencyioncurrent=electronsconcentrationxpulsefrequencywithnosample freq.=f°withelectronegativesample freq.=fssignaloutput=fs-f°=sampleconcentrationElectronCaptureDetectorConstantcurrentmethodModulatElectronCaptureDetectorRadioactivesource: Nickel63–370MBq(10mCi)Cellvolume 450LOperatingtemperaturelimit: 400°CMinimumdetectableamount: 10fgoflindaneLineardynamicrange: 104(argon/methane)
103(nitrogen)Operationmode: constantcurrentpulse-modulatedmodeReferencecurrent: 0to3nA(0.1nAsteps)Pulseamplitude: 5to50Vneg.Pulsewidth: 0.1s(argon/methane),
0.5s,1s(nitrogen)TechnicalSpecificationsElectronCaptureDetectorRadioElectronCaptureDetectorMolecularfeaturesgoverningtheresponseofECDLowresponseforalcohols,amines,phenols,aromaticsandvinyl
typefluorinatedhydrocarbonsHighresponseforhalocarboncompounds,nitroaromatics,and
conjugatedcompoundscontainingtwogroupswhichindividually
arenotstronglyelectronattractingbutbecomesowhen
connectedbyspecificbridgesResponsetowardsthehalogensdecreasesintheorderI>Br>Cl>FElectronCaptureDetectorMolecElectronCaptureDetectorMolecularfeaturesgoverningtheresponseofECDMultiplesubstitutionwithsimpleelectronattractinggroupsor
atomsmayincreasethemolecularabsorptionbyanamountmuch
greaterthanexpectedofasimpleadditiveeffectTheabsorptionconferredbyasimpleelectrophoricgroupisalso
sensitivetothepositioninthemoleculeSomeinorganiccompoundsareelectronabsorbers,ascarbon
disulfide,ozoneandtheoxidesofnitrogenElectronCaptureDetectorMolecElectronCaptureDetectorRelativesensitivityEthaneBenzene 1ButanolAcetoneChlorobutane 1-102Chlorobenzene1,2-dichlorobenzeneAntracene 102-104ChloroformNitrobenzene 104-105CarbontetrachlorideDinitrophenolDiethyloxalate 105-106DihydropyridineInfluenceofdetectortemperatureDetectionlimit(x10-9g)CCl4 0.010.010.01CHCl31.00.10.05CH2Cl21000408CH2ClCH2Cl1000201
80°C227°C350°CElectronCaptureDetectorRelatElectronCaptureDetectorRelativeresponseofhalocarbonsCF3CF2CF3 1.0CF3Cl 3.3CF2=CFCl 100CF3CF2Cl 170CF2=CCl2 670CF2Cl2 3x104CHCl3 3.3x104CHCl=CCl2 6.7x104CF3Br 8.7x104CF2ClCFCl2 1.6x105CF3CHClBr 4.0x105CF3CF2CF2I 6.0x105CF2BrCF2Br 7.7x105CFCl3 1.2x106ElectronCaptureDetectorRelatg-LINDANEMDA=10fgwithS/N=3ALDRIN(15pg)HEPTACHLOR(10pg)g-LINDANE(10pg)x2x64ECDperformanceMinimumDetectableAmountg-LINDANEMDA=10fgwithSBestconditionsforECDsensitivity
ECDsensitivityisaffectedbythefollowingfactors:
Referencecurrent
Thehigheristhereferencecurrent,thegreateristhesignalresponsebut
alsothebaselinenoise.TheS/Nrationeedstobe
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