Chlorprothixene-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEChlorprothixenehydrochlorideCat.No.:HY-B0274ACASNo.:6469-93-8分⼦式:C₁₈H₁₉Cl₂NS分⼦量:352.32作⽤靶点:DopamineReceptor;HistamineReceptor;Bacterial作⽤通路:GPCR/GProtein;NeuronalSignaling;Immunology/Inflammation;Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:2.5mg/mL(7.10mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.8383mL14.1916mL28.3833mL5mM0.5677mL2.8383mL5.6767mL10mM---------请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性Chlorprothixenehydrochloride⼀种多巴胺(dopamine)和组胺(histamine)受体拮抗剂，⾼亲和⼒地结合⼈D1，D2，D3，D5，H1受体，Ki分别为18nM，2.96nM，4.56nM，9nM和3.75nM。具有抗精神病作⽤[1]。IC50&TargetHumanD1ReceptorHumanD2ReceptorHumanD3ReceptorHumanD5Receptor18nM(Ki)2.96nM(Ki)4.56nM(Ki)9nM(Ki)1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEHumanH1Receptor3.75nM(Ki)体外研究Chlorprothixenebindsto5-HTreceptorswithpKisof8.3,8.5,and9.4for5-HT7,5-HT6and5-HT2,respectively[2].REFERENCES[1].YvonCoburg,etal.PotentialutilityofhistamineH3receptorantagonistpharmacophoreinantipsychotics.BioorgMedChemLett.2009Jan15;19(2):538-42.[2].BLRoth,etal.Bindingoftypicalandatypicalantipsychoticagentsto5-hydroxytryptamine-6and5-hydroxytryptamine-7receptors.JPharmacolExpTher.1994Mar;268(3):1403-10.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955