4-Ethynyl-L-phenylalanine-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE4-Ethynyl-L-phenylalanine hydrochlorideCat. No.: HY-23460ACAS No.: 188640-63-3分式: CHClNO分量: 225.67作靶点: Tryptophan Hydroxylase作通路: Metabolic Enzyme/Protease储存式: Please store the product under the recommended conditions inthe COA.

2、溶解性数据体外实验 Methanol : 125 mg/mL (553.91 mM; Need ultrasonic)DMSO : 100 mg/mL (443.12 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.4312 mL 22.1562 mL 44.3125 mL5 mM 0.8862 mL 4.4312 mL 8.8625 mL10 mM 0.4431 mL 2.2156 mL 4.4312 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。B

3、IOLOGICAL ACTIVITY物活性 4-Ethynyl-L-phenylalanine hydrochloride种选择性、可逆、效、竞争性的氨酸羟化酶 (TPH) 抑制剂。4-Ethynyl-L-phenylalanine hydrochloride 相对于底物氨酸具有竞争性作，Ki 值为 32.6 M。4-Ethynyl-L-phenylalanine hydrochloride 能选择性和可逆地抑制 5- 羟胺的物合成 1。IC50 & Target Ki: 32.6 M (TPH) 1体内研究4-Ethynyl-L-phenylalanine hydrochloride (30

4、 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the ratmidbrain but not in tissue 1.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE4-Ethynyl-L-phenylalanine hydrochloride is not inhibiting the aromatic amino acid decarboxylase 1.4-Ethynyl-L-phenylalanine hydrochloride has a low affinity for v

5、arious recombinant 5-HT receptors 1.Animal Model: Male Sprague-Dawley rats (200 g) 1Dosage: 30 mg/kgAdministration: Intraperitoneal injectionResult: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.REFERENCES1. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0