Adenosine-amine-congener-ADAC-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAdenosine amine congenerCat. No.: HY-128064CAS No.: 96760-69-9Synonyms: ADAC分式: CHNO分量: 576.6作靶点: Adenosine Receptor作通路: GPCR/G Protein储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外实验 DMSO : 31.

2、25 mg/mL (54.20 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.7343 mL 8.6715 mL 17.3430 mL5 mM 0.3469 mL 1.7343 mL 3.4686 mL10 mM 0.1734 mL 0.8672 mL 1.7343 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建

3、议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.61 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (3.61 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubilit

4、y: 2.08 mg/mL (3.61 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Adenosine amine congener (ADAC)种选择性的 A1 腺苷受体 (A1 adenosine receptor) 激动剂，可以改善噪和铂引起的蜗损伤。Adenosine amine congener 还具有神经保护作。IC50 & Target A1 adenosine receptor 1 2体外研究 Adenosine amine congener

5、 can reduce oxidative stress in the noise-exposed cochlea, leading to protectionof sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochleartissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection byAdenosine am

6、ine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibitionof voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways1.体内研究 Adenosine amine congener (25-300g/kg/day; intraperitoneal injection; daily; for 5 days; mal

7、e Wistar rats)treatment is most effective in the first 24 hours after noise exposure at doses 50g/kg, providing up to 21dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner 1.Animal Model: Male Wistar rats (8-10 weeks old) treated with noi

8、se exposure 1Dosage: 25 g/kg/day, 50 g/kg/day, 100 g/kg/day, 200 g/kg/day, and 300g/kg/dayAdministration: Intraperitoneal injection; daily; for 5 daysResult: Most effective in the first 24 hours after noise exposure at doses 50g/kg, and providedup to 21dB protection (averaged across 8-28kHz).REFEREN

9、CES1. Vlajkovic SM, et al. Adenosine amine congener as a cochlear rescue agent. Biomed Res Int. 2014;2014:841489.2. Vlajkovic SM, et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 2010 Jun;6(2):273-81.McePdfHeightCaution: Product has not been fully validated for medical