10β-17β-dihydroxyestra-1-4-dien-3-one-DHED-DataSheet-生命科学试剂-MedChemExpresssVIP

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE10,17-dihydroxyestra-1,4-dien-3-oneCat. No.: HY-128976CAS No.: 549-02-0Synonyms: DHED分式: CHO分量: 288.38作靶点: Estrogen Receptor/ERR作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 25

2、0 mg/mL (866.91 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.4676 mL 17.3382 mL 34.6765 mL5 mM 0.6935 mL 3.4676 mL 6.9353 mL10 mM 0.3468 mL 1.7338 mL 3.4676 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建

3、议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.21 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (7.21 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Maste

4、r of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.08 mg/mL (7.21 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 10,17-dihydroxyestra-1,4-dien-3-one (DHED)种靶向脑的雌激素 (estrogen) 前体。10,17-dihydroxyestra-1,4-dien-3-one (DHED)17-estradiol 的主物前药，可降低脑部温度调节功能障碍的发潮热 1。体内研究 10,17-dihydroxyestra-1,4-dien-3-one (D

5、HED), is an inactive bioprecursor prodrug of 17-estradiolconverting to 17-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach fordelivering E2 selectively into the brain for the potential treatment of hot flushes 1.REFERENCES1. Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17-estradiol alleviates hot flushes without hormonal effects inthe periphery. Sci Rep. 2016 Aug 1;6:30721.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37