药学中的生物技术和方法 0-Introduction

1、现代生物技术理论与实验药学中的生物技术和生物化学方法I - 生物技术绪论 药学研究和应用中的生物技术必备的生物学原理和知识本课程的教学安排现代药物研发基本过程先导化合物候选药物注册药物活性筛选临床前评价药物动力学性质药物毒性临床I、II、III期评价药物发现阶段药物开发阶段化合物Integrated drug discovery/development paradigmPreclinicalDevelopmentClinicalDevelopmentDiscoveryResearchRecipe for Success!化学合成物生物技术制药天然产物分离化合物库制备药物并行筛选&性质研究优化先

2、导/候选化合物 药物构效关系 药物构性关系 药物构毒关系新药产品开发药物临床验证药物发现/开发合理药物设计 基于结构 基于机理 性质改造药学生物方法和生物技术Drug designStructural & molecular biological methodsDrug synthesis:Biotransformation and Synthetic BiologyDrug screening/evaluation:Biological molecule-based assaysCell-based assaysAnimal-based assaysRational drug deliver

3、yBiopharmaceutical methods药物学家 必备素养Biology & Systems BiologyBiochemistryPharmaceutical ChemistryMedicinal chemistryEnvironmental Chemistry & Green synthesisChemical biologySynthetic biologyPharmacologyMolecular biochemistry教学安排崔景荣分子生物学技术蒲小平细胞培养及分析相关技术曾慧慧生物氧化和抗氧化剂筛选杨晓达：生物药物技术免疫分析方法ADMET方法教材和习题PBL sem

4、inarPBL课堂的考试分数占30%分组：本学期学生人数共118人。每组4人, 共27组，如本班不足4人的可与其他班学生组成4人每次seminar有78组的学生讲述（105分钟）每组针对一个问题，讲15分钟，其中讲述12分钟，提问3分钟8.28各班交分组和选题名单，分组前请与崔景荣联系;PPT的要求包括4方面内容：问题的提出；解决问题的方法；采用现代技术的基本原理；总结并提出新的思路。第一次seminar的问题抗体和核酸适配子的分析化学非天然氨基酸标记蛋白质技术及其应用Synthetic biology专题讨论 Synthetic biology: overview

5、(innovations and possible downsides)Synthetic biology and organic synthesisSynthetic biology and drug discovery and biomedical applicationsSynthetic biology and metabolic engineeringSynthetic biology and biofuel一些启发读物for synthetic biologyMolecular Systems Biology 2:2006.0028，Synthetic biology: new e

6、ngineering rules for an emerging disciplineNature Reviews Molecular Cell Biology 10, 410-422 (June 2009), The second wave of synthetic biology: from modules to systemsNature Reviews Genetics 11, 367-379 (May 2010),Synthetic biology: applications come of ageScience 2 September 2011:Vol. 333 no. 6047

7、pp. 1244-1248,Synthetic Biology: Integrated Gene Circuits Nature 483, 29 (01 March 2012),Synthetic biology: Four steps to avoid a synthetic-biology disasterChemistry & Biodiversity,Volume 4, Issue 4, pages 603621, April 2007, Chemical Aspects of Synthetic BiologyNature Chemical Biology 3, 521 - 525

8、(2007),Synthetic biology: lessons from the history of synthetic organic chemistryCurrent Opinion in Biotechnology,Volume 20, Issue 4, August 2009, Pages 498503,Chemical synthesis using synthetic biologyChem. Soc. Rev. , 2010, 39, 286-300,Controlled polymer synthesisfrom biomimicry towards synthetic

9、biologyDrug Discovery Today,Volume 14, Issues 1920, October 2009, Pages 956963,The impact of synthetic biology on drug discovery Nature Biotechnology 29, 693695 (2011) , Synergies between synthetic biology and metabolic engineeringMetabolic Engineering,Volume 14, Issue 3, May 2012, Pages 189195,Synt

10、hetic Biology: New Methodologies and Applications for Metabolic EngineeringSynthetic biology and the development of tools for metabolic engineering Current Opinion in Biotechnology,Volume 19, Issue 6, December 2008, Pages 556563,Metabolic engineering of microorganisms for biofuels production: from b

11、ugs to synthetic biology to fuels Applied Microbiology and Biotechnology,March 2010, Volume 86, Issue 2, pp 419-434,Biofuel production in Escherichia coli: the role of metabolic engineering and synthetic biology Science 2 September 2011:Vol. 333 no. 6047 pp. 1248-1252,Synthetic Biology Moving into the Clinic Nature Reviews Genetics 13, 21-35 (January 2012) , Emerging biomedical applications of synthetic biology 2005 Nanotechnology 16 R1 doi:10.1088/0957-4484/16/1/R01, Synthetic biology for nanotechnology 2006 Molecular Systems Biology 2:69,Cell-fre