6-Hydroxyflavone-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE6-HydroxyflavoneCat. No.: HY-N7110CAS No.: 6665-83-4分式: CHO分量: 238.24作靶点: Others作通路: Others储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 125 mg/mL (524.68 mM; Need ul

2、trasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.1974 mL 20.9872 mL 41.9745 mL5 mM 0.8395 mL 4.1974 mL 8.3949 mL10 mM 0.4197 mL 2.0987 mL 4.1974 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当

3、保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (8.73 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (8.73 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 6-Hydroxyfla

4、vone种天然存在的酮化合物，具有抗炎作。6-Hydroxyflavone 对红蛋 (BHb) 糖基化具有抑制作。6-Hydroxyflavone 能激活 AKT、ERK 1/2、JNK 信号通路，有效促进成细胞分化。6-Hydroxyflavone 能抑制 LPS 诱导的 NO 的产 1 2。REFERENCES1. Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectrosc

5、opic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52.2. Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med.2014;2014:924560.3. Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylatedflavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10(3):e0116409.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37