《磁共振成像》课件

1、Calix4arenes as Molecular Platforms for Magnetic Resonance Imaging (MRI) Contrast AgentsThe PaperOutlineConclusion3Introduction1Experimental Section 21、 IntroductionMolecular imaging It seems to take photos of molecular , display the morphological structure of our target. In other words, characteriz

2、ation and measurement of the process of living animals, human biology and model system in the cellular and molecular level using the imaging detector in vitro .Features of molecular imaging Non-invasive imaging technique Dynamic acquisition Reflect full-scaleSome main imaging techniques Positron emi

3、ssion tomography (PET) Single photon emission computed tomography (SPECT) Magnetic resonance imaging (MRI) Ultrasonic imaging Optical imaging (Bioluminescence ,Fluorescence )MRIMagnetic resonance imaging (MRI) is one of the most important techniques in medical imaging.It is noninvasive, avoids probl

4、ems occurring in other imaging techniques such as scattering (optical imaging) or high-energy radiation (computed tomography (CT) or X-ray), and enables the production of 3D images of various tissues.The challenge is to prepare complexes that do not release the toxic metal ion in vivo and yet are ef

5、ficient contrast agents.One of approaches to find systems with optimal R is to use the rather rigid calix4arene core as a synthetic platform.Calixarenes generally enable the introduction of at least two different functions.AggregationVariable-temperature 17O NMR measurementsWithin the experimental e

6、rror, the hyperfine coupling constant is identical to commonly observed values for oxygen atoms directly coordinated to Gd.The electronic parameters are in the same range as thoseof the micellar aggregates and of the monomer.3、ConclusionThe novel noncharged self-aggregating calix4arene-based MRI contrast agent described here exhibits good relaxivities over a broad range of Lamor frequencies.Evaluation of the parameters governing the relaxivity shows that it is limited by the average residence time of water in the first coordination sphere of GdIII. Investigations to further improve the eff