UAMC-3203-hydrochloride - Ferroptosis 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEUAMC-3203 hydrochlorideCat. No.: HY-112909ACAS No.: 2271358-65-5分式: CHClNOS分量: 508.12作靶点: Ferroptosis作通路: Apoptosis储存式: 4C, sealed storage, away from moisture and light* In solvent : -80C, 6 months; -20C, 1 month (sealedstorage,

2、 away from moisture and light)溶解性数据体外实验 DMSO : 50 mg/mL (98.40 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9680 mL 9.8402 mL 19.6804 mL5 mM 0.3936 mL 1.9680 mL 3.9361 mL10 mM 0.1968 mL 0.9840 mL 1.9680 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的

3、溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.09 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (4.09 mM); Clear so

4、lution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.09 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 UAMC-3203 hydrochloride是有效，选择性的 Ferroptosis 抑制剂，IC50 为 12 nM 1。IC50 & Target IC50: 12 nM (Ferroptosis) 1体内研究 No toxicity is observed in mic

5、e after repeated injections of UAMC-3203 (20 mol/kg; injectedintraperitoneally; daily, over a period of 4 weeks) 1.Animal Model: Wild type mice derived from a Gpx4 fl/fl breeding 1Dosage: 20 mol/kgAdministration: Injected intraperitoneally; daily, over a period of 4 weeksResult: No toxicity was observed.REFERENCES1. Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3