RP-54745 - Interleukin Related 抑制剂 - 生命科学试剂 - MedChemExpressVIP

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERP-54745Cat. No.: HY-101716CAS No.: 135330-08-4分式: CHClNOS分量: 297.82作靶点: Interleukin Related作通路: Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 62.5 mg/mL (209.86 mM

2、; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.98 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.98 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 RP-54745种潜在的治风湿化合物，能够抑制噬细胞刺激和的介素-1 (inte

3、rleukin-1) 的产。体外研究 RP-54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages 1.体内研究 RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis andin the MRL/lpr mice, genetically predisposed to develop an autoimmune

4、pathology including arthriticdisorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunologicalparameters, improved after a 3-month treatment with RP-54745 2.REFERENCES1. Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrop

5、hage stimulation and interleukin-1 production.Agents Actions. 1992 May;36(1-2):119-26.2. Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992May;36(1-2):127-35.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58