Retapamulin-SB-275833-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERetapamulinCat. No.: HY-17010CAS No.: 224452-66-8Synonyms: SB-275833分式: CHNOS分量: 517.76作靶点: Bacterial作通路: Anti-infection储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO :

2、52 mg/mL (100.43 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9314 mL 9.6570 mL 19.3140 mL5 mM 0.3863 mL 1.9314 mL 3.8628 mL10 mM 0.1931 mL 0.9657 mL 1.9314 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Retapamulin(SB-275833)局

3、部抗素，能结合 葡萄球 和肠杆菌核糖体，Kd为3 nM。REFERENCES1. Kircik LH.Efficacy and tolerability of retapamulin 1% ointment for the treatment of infected atopic dermatitis: a pilot study.J DrugsDermatol. 2012 Jul 1;11(7):858-60.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. Candel FJ, Morales G, Picazo JJ.In vitro

4、 activity of retapamulin against linezolid and methicillin-resistant Staphylococcus aureusisolates.Rev Esp Quimioter. 2011 Sep;24(3):127-30.3. Prez-Trallero E, Tamayo E, Montes M, Garca-Arenzana JM, Iriarte V.In vitro activities of retapamulin and 16 other antimicrobial agentsagainst recently obtain

5、ed Streptococcus pyogenes isolates.Antimicrob Agents Chemother. 2011 May;55(5):2406-8.4. Weinberg JM, Tyring SK.Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcusaureus.J Drugs Dermatol. 2010 Oct;9(10):1198-204.5. Retapamulin: focus on its use in the treatment of uncomplicated superficial skin infections and impetigo By Jacobs, Michael R.FromExpert Review of Dermatology (2010), 5(5), 505-517.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3