Ro-61-8048-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERo 61-8048Cat. No.: HY-12347CAS No.: 199666-03-0分式: CHNOS分量: 421.45作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 59 mg/mL (139.99 mM)* means soluble, but saturation

2、unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3728 mL 11.8638 mL 23.7276 mL5 mM 0.4746 mL 2.3728 mL 4.7455 mL10 mM 0.2373 mL 1.1864 mL 2.3728 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ro 61-8048种有效的和选择性尿氨酸羟化酶（kynurenine hydroxylase）抑制剂，IC50为37 nM。REFERENCES1

3、. Rover S, et al. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors ofkynurenine 3-hydroxylase. J Med Chem. 1997 Dec 19;40(26):4378-85.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. Cozzi A, et al. Kynurenine hydroxylase inhibitors r

4、educe ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-N-4-(nitrophenyl)thiazol-2yl-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia. J C3. Hamann M, et al. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia inthe dt sz mutant. Eur J Pharmacol. 2008 May 31;586(1-3):156-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;