Pinacidil-monohydrate - Potassium Channel - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPinacidil monohydrateCat. No.: HY-14290ACAS No.: 85371-64-8分式: CHNO分量: 263.34作靶点: Potassium Channel作通路: Membrane Transporter/Ion Channel储存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 Ethanol : 50 mg/mL (18

2、9.87 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.7974 mL 18.9869 mL 37.9737 mL5 mM 0.7595 mL 3.7974 mL 7.5947 mL10 mM 0.3797 mL 1.8987 mL 3.7974 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；

3、澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.49 mM); Clear solution2. 请依序添加每种溶剂： 10% EtOH 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.49 mM); Clear solution3. 请依序添加每种溶剂： 10% EtOH 90% corn oilSolubility: 2.5 mg/m

4、L (9.49 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Pinacidil monohydrate，种抗压药，种钾通道激活剂。体外研究 Pinacidil monohydrate is a potassium channel activator 1. Pinacidil hydrate is an antihypertensive drug ofthe class of agents called potassium channel openers 2.

5、 Pinacidil hydrate activates the ATP-modulatedpotassium channels of guinea pog bladder and heart with Ki values of 104 and 251 nM, respectively 3.REFERENCES1. Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smoothmuscle, a

6、nd blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86.2. Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5.3. Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smoothmuscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use on