Skepinone-L-CBS3830-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESkepinone-LCat. No.: HY-15300CAS No.: 1221485-83-1Synonyms: CBS3830分式: CHFNO分量: 425.42作靶点: p38 MAPK作通路: MAPK/ERK Pathway储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (117.53 mM)H

2、2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.88 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (5.88 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Skepinone-L (CBS3830)是选择性p38 MAPK抑制剂。IC50 & Target p38MAPK 1.

3、体外研究 Skepinone-L (CBS3830), the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy andselectivity. Therefore, Skepinone-L (CBS3830) is a valuable probe for chem. biol. research, and it may fosterthe development of a unique class of kinase inhibitors.REFERENCES1. Koeberle, Solve

4、igh C.; Romir, Johannes; Fischer, Stefan et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.Nature Chemical Biology (2012), 8(2), 141-143.2. Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter et al. Design, Synthesis, and Biological Evaluation of Novel DisubstitutedDibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase. Journal of Medicinal Chemistry(2012), 55(12), 5868-5877.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559