NGI-1-ML414-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENGI-1Cat. No.: HY-117383CAS No.: 790702-57-7Synonyms: ML414分式: CHNOS分量: 394.51作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 160 mg/mL (405.57 mM; Need ultrasonic)Mas

2、s Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5348 mL 12.6740 mL 25.3479 mL5 mM 0.5070 mL 2.5348 mL 5.0696 mL10 mM 0.2535 mL 1.2674 mL 2.5348 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百

3、分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.67 mg/mL (6.77 mM); Clear solution; Need warmingBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 NGI-1种细胞渗透性抑制剂。体外研究 NGI-1 blocks EGFR N-linked glycosylation in lung adenocarcinoma cells as assessed. In contr

4、ols EGFR isbiotinylated, consistent with its plasma membrane expression, but in NGI-1 treated cells the EGFR ispredominantly found in the non-biotinylated intracellular fraction suggesting a change in cellular localization 1.REFERENCES1. Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016Dec;12(12):1023-1030.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F