Cetrorelix-Acetate-SB-075-acetate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECetrorelix AcetateCat. No.: HY-P0009ACAS No.: 145672-81-7Synonyms: SB-075 acetate; NS-75A分式: CHClNO分量: 1491.09Sequence: N-acetyl-2-Naph-Ala-Cl-Phe-3Py-Ala-Ser-Tyr-Cit-Leu-Arg-Pro-Ala-NH2Sequence Shortening: Ac-2-Naph-Ala-Cl-Phe-

2、3Py-Ala-SY-Cit-LRPA-NH2作靶点: GNRH Receptor作通路: GPCR/G Protein储存式: Protect from lightPowder -80C 2 years-20C 1 yearIn solvent -80C 6 months-20C 1 month* 该产品在溶液状态不稳定，建议您现现配，即刻使。溶解性数据体外实验 DMSO : 50 mg/mL (33.53 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 0.6707 mL 3.3533 mL 6.

3、7065 mL5 mM 0.1341 mL 0.6707 mL 1.3413 mL10 mM 0.0671 mL 0.3353 mL 0.6707 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 Cetrorelix Acetate是GnRH 受体的强效拮抗剂，其 IC50 值为 1.21 nM。IC50 & Target IC50: 1.21 nM GnRH 1.体外研究 Cetrorelix Acetat

4、e inhibits growth of ES-2 cell line at 1000 ng/ml. Cetrorelix Acetate has comparableantiproliferative effects as GnRH-I agonists indicating that the dichotomy of GnRH-I agonists and antagonistsmight not apply to the GnRH-I system in cancer cells 2.REFERENCES1. Beckers T et al. Characterization of go

5、nadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter geneassay. Anal Biochem. 1997 Aug 15;251(1):17-23.2. Grndker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5