NVP-ADW742-ADW742-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENVP-ADW742Cat. No.: HY-10252CAS No.: 475488-23-4Synonyms: ADW742; GSK 552602A; ADW分式: CHNO分量: 453.58作靶点: IGF-1R作通路: Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO

2、: 25 mg/mL (55.12 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2047 mL 11.0234 mL 22.0468 mL5 mM 0.4409 mL 2.2047 mL 4.4094 mL10 mM 0.2205 mL 1.1023 mL 2.2047 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的

3、作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.51 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.51 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLO

4、GICAL ACTIVITY物活性 NVP-ADW742(ADW742; GSK 552602A )IGF-1R选择性抑制剂，IC50为170nM，对InsR的抑制性强16倍，对HER2，PDGFR，VEGFR-2，Bcr-Abl和c-Kit活性极低。户使本产品发表的科研献 Blood. 2018 Jul 12;132(2):210-222.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Mitsiades CS, et al. Inhibition of the insulin-like growth

5、 factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiplemyeloma, other hematologic malignancies, and solid tumors. Cancer Cell. 2004 Mar;5(3):221-30.2. Warshamana-Greene GS, et al. The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination withSTI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Mol Cancer Ther. 2004May;3(5):527-35.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3