all-trans-4-Oxoretinoic-acid-all-trans-4-Keto-Retinoic-Acid-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEall-trans-4-Oxoretinoic acidCat. No.: HY-107494ACAS No.: 38030-57-8Synonyms: all-trans 4-Keto Retinoic Acid分式: CHO分量: 314.42作靶点: Endogenous Metabolite作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80

2、C 6 months-20C 1 month溶解性数据体外实验 DMSO : 150 mg/mL (477.07 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.1805 mL 15.9023 mL 31.8046 mL5 mM 0.6361 mL 3.1805 mL 6.3609 mL10 mM 0.3180 mL 1.5902 mL 3.1805 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制

3、前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.95 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.95 mM); Clear solution3.

4、 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (7.95 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 all-trans-4-Oxoretinoic acid，维素A 的活性代谢物，可通过作核维甲酸受体 (RARs) 来诱导基因转录。IC50 & Target Human Endogenous Metabolite体外研究 all-trans-4-Oxoretinoic acid, an act

5、ive metabolite of vitamin A, induces gene transcription via binding tonuclear retinoic acid receptors (RARs) 1. all-trans-4-Oxoretinoic acid is a biologically active geometricisomer of retinoic acid (RA) 2.REFERENCES1. Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence

6、 that CYP26A1 is an important enzyme in theelimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41.2. Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2cells. Adv Exp Med Biol. 1996;387:121-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400