Imidapril-hydrochloride-TA-6366-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEImidapril hydrochlorideCat. No.: HY-B1451CAS No.: 89396-94-1Synonyms: TA-6366分式: CHClNO分量: 441.91作靶点: Angiotensin-converting Enzyme (ACE)作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20

2、C 1 month溶解性数据体外实验 H2O : 50 mg/mL (113.15 mM; Need ultrasonic)DMSO : 50 mg/mL (113.15 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2629 mL 11.3145 mL 22.6290 mL5 mM 0.4526 mL 2.2629 mL 4.5258 mL10 mM 0.2263 mL 1.1315 mL 2.2629 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限

3、。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.66 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/m

4、L (5.66 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.66 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Imidapril hydrochloride (TA-6366)管紧张素转换酶 (ACE) 抑制剂，具有抗压活性。IC50 & Target ACE体外研究 As a prodrug, Imidapril is converted by

5、 hydrolysis in the liver into its active form imidaprilat. Imidaprilatcompetitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II.This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat alsodecreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase insodium excretion and subsequently increases water outflow.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3