Mitotane-2-4-DDD-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMitotaneCat. No.: HY-13690CAS No.: 53-19-0Synonyms: 2,4-DDD; o,p-DDD分式: CHCl分量: 320.04作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (312.46 mM)* means solu

2、ble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.1246 mL 15.6230 mL 31.2461 mL5 mM 0.6249 mL 3.1246 mL 6.2492 mL10 mM 0.3125 mL 1.5623 mL 3.1246 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，

3、当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.81 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.81 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTI

4、VITY物活性 Mitotane(2,4-DDD)DDD的同分异构体和DDT的衍物，有抗癌活性，可作于肾上腺质癌。REFERENCES1. Gentilin E, Tagliati F, Terzolo M, Mitotane reduces human and mouse ACTH-secreting pituitary cell viability and function. J Endocrinol.2013 Jul 29;218(3):275-285.2. Lehmann TP, Wrzesiski T, Jagodziski PP. The effect of mitotane on

5、 viability, steroidogenesis and gene expression in NCI H295Radrenocortical cells. Mol Med Rep. 2013 Mar;7(3):893-900.3. Takeshita A, Igarashi-Migitaka J, Koibuchi N, Mitotane induces CYP3A4 expression via activation of the steroid and xenobiotic receptor.J Endocrinol. 2013 Feb 15;216(3):297-305.4. E

6、derhy S, Cohen A, Dufaitre G, No evidence for relevant QT interval prolongation in mitotane-treated patients with adrenocorticalcarcinoma. J Endocrinol Invest. 2012 Nov;35(10):911-4.5. Alexandraki KI, Kaltsas GA, le Roux CW, Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated withmitotane: a pilot study. Clin Endocrinol (Oxf). 2010 Mar;72(3):305-11.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te