2-Thiouracil-Thiouracil-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE2-ThiouracilCat. No.: HY-B0503CAS No.: 141-90-2Synonyms: Thiouracil分式: CHNOS分量: 128.15作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (390.17 mM; Need ultraso

2、nic)H2O : 0.67 mg/mL (5.23 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 7.8034 mL 39.0168 mL 78.0336 mL5 mM 1.5607 mL 7.8034 mL 15.6067 mL10 mM 0.7803 mL 3.9017 mL 7.8034 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果

3、的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 3.75 mg/mL (29.26 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 3.75 mg/mL (29.26 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www

4、.MedChemEBIOLOGICAL ACTIVITY物活性 2-Thiouracil硫醇盐尿嘧啶衍物，有抗甲亢效果。REFERENCES1. Palumbo, A., M. dIschia, and F.A. Cioffi, 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonisingtetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-1

5、2.2. Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem,1996. 39(26): p. 5192-201.3. Nagasaka, A. and H. Hidaka, Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroidiodine peroxidase. J Clin Endocrinol Metab, 1976. 43(1): p. 152-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;