Arterolane-OZ-277-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEArterolaneCat. No.: HY-10852CAS No.: 664338-39-0Synonyms: OZ 277; RBx 11160分式: CHNO分量: 392.53作靶点: Parasite作通路: Anti-infection储存式: -20C, protect from light, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (prote

2、ct fromlight, stored under nitrogen)溶解性数据体外实验 DMSO : 100 mg/mL (254.76 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5476 mL 12.7379 mL 25.4758 mL5 mM 0.5095 mL 2.5476 mL 5.0952 mL10 mM 0.2548 mL 1.2738 mL 2.5476 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物

3、和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.67 mg/mL (4.25 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.67 mg/mL (4.25 mM);

4、 Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 1.67 mg/mL (4.25 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Arterolane种抗疟疾剂，对 P. falciparum Ro73 和 W2 的 IC50 值均为 1.1 nM。IC50 & Target IC50: 1.1 nM (P. falciparum Ro73), 1.1 nM (P. falciparum

5、 W2) 1体外研究 Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1 nM (0.43ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity againstseveral other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, a

6、nd 0.84 ng/mL for P.falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively 1.REFERENCES1. Vennerstrom JL, et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 2004 Aug19;430(7002):900-4.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-