R-minus-JQ1-Enantiomer-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(R)-(-)-JQ1 EnantiomerCat. No.: HY-13030ACAS No.: 1268524-71-5分式: CHClNOS分量: 456.99作靶点: Epigenetic Reader Domain作通路: Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (21

2、8.82 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1882 mL 10.9412 mL 21.8823 mL5 mM 0.4376 mL 2.1882 mL 4.3765 mL10 mM 0.2188 mL 1.0941 mL 2.1882 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的

3、可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (6.02 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (6.02 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% co

4、rn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.75 mg/mL (6.02 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 (R)-(-)-JQ1 Enantiomer(+)-JQ1的异构体。(+)-JQ1可降低 BRD4 因表达，(R)-(-)-JQ1 Enantiomer 没有此作效果。IC50 & Target BET bromodomain 1体外研究 (R)-(-)-JQ1 Enantiomer shows no significant interactio

5、n with any bromodomain. Besides, (R)-(-)-JQ1Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC) 1.户使本产品发表的科研献 EMBO Mol Med. 2018 Apr;10(4). pii: e8163. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2961-2966. J Mol Cell Cardiol. 2018 Dec 7;127:83-96. Sci Re

6、p. 2018 Aug 1;8(1):11554. Harvard Medical School LINCS LIBRARYSee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.2. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO MolMed. 2018 Apr;10(4). pii: e8163.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te