PGD2-IN-1-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPGD2-IN-1Cat. No.: HY-101430CAS No.: 885066-67-1分式: CHClNO分量: 460.35作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 25 mg/mL (54.31 mM)* means soluble, but saturation

2、unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1723 mL 10.8613 mL 21.7226 mL5 mM 0.4345 mL 2.1723 mL 4.3445 mL10 mM 0.2172 mL 1.0861 mL 2.1723 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 PGD2-IN-1DP受体拮抗剂, 来专利专利WO 2006044732 A2，化合物实例15 (d)， IC50值为0.3 nM。IC50 & T

3、arget IC50: 0.3 nM 1体外研究Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It islargely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEcells. Blockage of

4、PGD2 using DP antagonistshave been shown to be effective at alleviating the symptoms ofallergic rhinitis in multiple species and more specifically have been shown to inhibit the antigen-induced nasalcongestion 1.REFERENCES1. Patent: WO/2006/044732A22. Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F