GSK2981278 - ROR Modulator - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGSK2981278Cat. No.: HY-19770CAS No.: 1474110-21-8分式: CHNOS分量: 461.61作靶点: ROR作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (216.63 mM)* means solubl

2、e, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1663 mL 10.8317 mL 21.6633 mL5 mM 0.4333 mL 2.1663 mL 4.3327 mL10 mM 0.2166 mL 1.0832 mL 2.1663 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使

3、；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.42 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.42 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Smal

4、l Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (5.42 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 GSK2981278种维甲酸相关孤受体（RORy）调节剂, 详细信息请参考专利献WO /2015061515 A1。REFERENCES1. Birault Veronique, et al. Preparation of tetrahydropyranylmethoxy benzenesulfonamide compounds as ROR modulators useful intherap

5、y of various diseases. From PCT Int. Appl. (2015), WO 2015061515 A1 20150430.2. Birault Veronique, et al. Preparation of tertiary N-arylbenzenesulfonamides as ROR modulators useful in treatment of inflammatory,metabolic, and autoimmune diseases. From PCT Int. Appl. (2013), WO 2013160418 A1 20131031.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021