Arenobufagin - Steroid - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEArenobufaginCat. No.: HY-N0876CAS No.: 464-74-4分式: CHO分量: 416.51作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 Ethanol : 10 mg/mL (24.01 mM; Need ultrasonic)Mass Solvent1 mg

2、 5 mg 10 mg Concentration制备储备液1 mM 2.4009 mL 12.0045 mL 24.0090 mL5 mM 0.4802 mL 2.4009 mL 4.8018 mL10 mM 0.2401 mL 1.2005 mL 2.4009 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液

3、中的体积占)：1. 请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% salineSolubility: 1 mg/mL (2.40 mM); Clear solution2. 请依序添加每种溶剂： 10% EtOH 90% (20% SBE-CD in saline)Solubility: 1 mg/mL (2.40 mM); Clear solution3. 请依序添加每种溶剂： 10% EtOH 90% corn oilSolubility: 1 mg/mL (2.40 mM); Clear solution1/2 Master of Smal

4、l Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 沙蟾蜍精(Arenobufagin)是由蟾蜍毒液提取的蟾蜍甾烯，具有抗癌活性。户使本产品发表的科研献 Molecules. 2017 Sep 11;22(9). pii: E1525.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Zhang DM, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apop

5、tosis and autophagy in human hepatocellularcarcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013 Jun;34(6):1331-42.2. Li M, et al. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression ofVEGFR-2 signaling pathway.

6、Biochem Pharmacol. 2012 May 1;83(9):1251-60.3. Cruz Jdos S, et al. Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes. Eur J Pharmacol.1993 Aug 3;239(1-3):223-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820